Antiproliferative cardenolides of an Elaeodendron sp. from the Madagascar rain forest(1).

Antiproliferative cardenolides of an Elaeodendron sp. from the Madagascar rain forest(1). Research Abstract Details 

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Antiproliferative cardenolides of an Elaeodendron sp. from the Madagascar rain forest(1). Abstract Text:

Shugeng Cao,Peggy J Brodie,James S Miller,Fidy Ratovoson,Martin W Callmander,Sennen Randrianasolo,Etienne Rakotobe,Vincent E Rasamison,Edward M Suh,Karen TenDyke,David G I Kingston,

Bioassay-guided fractionation of an ethanol extract obtained from the Madagascar plant Elaeodendron sp. led to the isolation of two new cardenolides, elaeodendrosides T and U (1 and 2). The structures of the new compounds were elucidated using 1D and 2D NMR experiments and mass spectrometry. Compounds 1, 3, 4, and 5 showed significant antiproliferative activity against A2780 human ovarian cancer cells with IC50 values of 0.085, 0.019, 0.19, and 0.10 microM, respectively, while compounds 2 and 6 were less active.

Antiproliferative cardenolides of an Elaeodendron sp. from the Madagascar rain forest(1). Publishing Authors By Initials

S Cao,PJ Brodie,JS Miller,F Ratovoson,MW Callmander,S Randrianasolo,E Rakotobe,VE Rasamison,EM Suh,K TenDyke,DG Kingston,

For similar plants: plants, medicinal research abstracts see: plants: plants, medicinal research

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Antiproliferative cardenolides of an Elaeodendron sp. from the Madagascar rain forest(1). Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of natural products

VOLUME: 70

Page Numbers: 1064-7

Journal Abbreviation: J. Nat. Prod.

ISSN: 0163-3864

DAY: 5

MONTH: 06

YEAR: 2007

Antiproliferative cardenolides of an Elaeodendron sp. from the Madagascar rain forest(1). Information

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LANGUAGE: eng

NlmUniqueID: 7906882

Antiproliferative cardenolides of an Elaeodendron sp. from the Madagascar rain forest(1). Keywords Mesh Terms:

KEYWORDS: Plants, Medicinal

MESH TERMS: chemistry

Chemical & Substance for Abstract: Antiproliferative cardenolides of an Elaeodendron sp. from the Madagascar rain forest(1). Information

Substance Name: elaeodendroside U

Registry Number: 0

Grant and Affiliation Information for Antiproliferative cardenolides of an Elaeodendron sp. from the Madagascar rain forest(1).

AFFILIATION: Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA.

Country: United States

AGENCY: United States FIC

GRANT: U01 TW00313

ACRONYM: TW

MEDLINETA: J Nat Prod

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