Antiplatelet agents and randomized trials.

Antiplatelet agents and randomized trials. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Antiplatelet agents and randomized trials. Abstract Text:

Hans-Christoph Diener,Hans-Christoph Diener,Hans-Christoph Diener,

Patients who have transient ischemic attack (TIA) or ischemic stroke are at a high risk of having a first or recurrent stroke. The annual risk is between 5% and 15%; the risk is highest in the first 48 hours following a TIA and highest in the first 7 days following an ischemic stroke. Secondary prevention includes antithrombotic therapy, treatment of risk factors, and interventional treatment of carotid stenosis. Antithrombotic options can include antiplatelet drugs such as aspirin, aspirin plus extended-release dipyridamole (ER-DP), clopidogrel, or clopidogrel plus aspirin. Oral anticoagulation is used in patients with a cardiac source of embolism such as atrial fibrillation. Aspirin monotherapy offers a modest risk reduction for recurrent stroke and for the combined endpoint of nonfatal stroke, myocardial infarction (MI), and vascular death. The combination of ER-DP and aspirin was shown to be superior to aspirin monotherapy in several trials. Clopidogrel is superior to aspirin in high-risk patients suffering from stroke, MI, or peripheral arterial disease. The combination of clopidogrel plus aspirin is not superior to aspirin or clopidogrel monotherapy and carries a significantly higher bleeding risk. The combination might offer benefit in short-term secondary prevention after TIA or stroke. Another ongoing trial is currently investigating the possible benefit and side effects of aspirin plus ER-DP versus clopidogrel in secondary stroke prevention.

Antiplatelet agents and randomized trials. Publishing Authors By Initials

HC Diener,HC Diener,HC Diener,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Antiplatelet agents and randomized trials. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Reviews in neurological diseases

VOLUME: 4

Page Numbers: 177-83

Journal Abbreviation:

ISSN: 1545-2913

DAY: 15

MONTH: 01

YEAR: 2007

Antiplatelet agents and randomized trials. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101223246

Antiplatelet agents and randomized trials. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Antiplatelet agents and randomized trials. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Antiplatelet agents and randomized trials.

AFFILIATION: Department of Neurology, University Dusiburg-Essen, Essen, Germany.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Rev Neurol Dis

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Antiplatelet agents and randomized trials Related Publications

• A personal view of the classification and definition of drug dependence headache.
• Antiplatelet agents and randomized trials.
• Ca( 2+ )-induced cl (-) efflux at rat distal colonic epithelium.
• Clopidogrel versus aspirin in patients with atherothrombosis: CAPRIE-based calculation of cost-effectiveness for Germany.
• Cortical activation in hemianopia after stroke.
• Effect of active treatment is lower when using placebo control in clinical trials on acute therapy of migraine.
• Effect of carbon dioxide, temperature, and relative humidity on production of aflatoxin in peanuts.
• Efficacy and safety of 1,000 mg effervescent aspirin: individual patient data meta-analysis of three trials in migraine headache and migraine accompanying symptoms.
• How can PET scans help us understand headache mechanisms?
• Low-dose aspirin for migraine prophylaxis in women.
• Low-dose ibuprofen in self-medication of mild to moderate headache: a comparison with acetylsalicylic acid and placebo.
• Placebo in headache trials.
• RPR100893, a substance-P antagonist, is not effective in the treatment of migraine attacks.
• Saccade induced cortical activation in patients with post-stroke visual field defects.
• Se02 the validity of an integrated clinical simulator for learning laparoscopic appendicectomy.
• Stimulation of voltage-dependent Ca2+ channels by NO at rat myenteric neurons.
• Sumatriptan in the treatment of cluster headache.
• Sumatriptan: vasoactive effect on human dural vessels, demonstrated by subselective angiography.
• Systemic Risk Score Evaluation in Ischemic Stroke Patients (SCALA) : A prospective cross sectional study in 85 German stroke units.
• Trigeminal autonomic cephalalgias: a case of post-traumatic SUNCT syndrome?
• Use of almotriptan in triptan-experienced and triptan-naïve patients.
• [Abortion after the 12th completed pregnancy week. Report of experience of a specialist commission]
• [Development of a screening tool for migraine prophylaxis]
• [Incidence of hidden iron deficiency in women, especially in pregnancy and puerperium.]
• [Monitoring stroke units: management, outcome, efficiency]
• [On the applicability of vaginal cytology in the determination of delivery term and in the recognition of prolonged pregnancy]
• [Pathogenesis of anemia in myomas.]
• [Results in the management of pregnancies involving risk factors]
• [Serologic toxoplasmosis control in pregnancy using enzyme immunoassay (EIA). 1st experiences]
• [The change of cervical state during pregnancy (author's transl)]