Antiplasmodial activity of compounds from Sloanea rhodantha (Baker) Capuron var. rhodantha from the Madagascar rain forest.

Antiplasmodial activity of compounds from Sloanea rhodantha (Baker) Capuron var. rhodantha from the Madagascar rain forest. Research Abstract Details 

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Antiplasmodial activity of compounds from Sloanea rhodantha (Baker) Capuron var. rhodantha from the Madagascar rain forest. Abstract Text:

Shugeng Cao,Lalasoa Ranarivelo,Michel Ratsimbason,Sennen Randrianasolo,Fidy Ratovoson,Mamisoa Andrianjafy,David G I Kingston,

Bioassay-directed separation of the butanol-soluble portion of an extract of Sloanea rhodantha (Baker) Capuron var. Rhodantha (Elaeocarpaceae) active against the drug-sensitive HB3 strain of Plasmodium falciparum led to the isolation of seven phenolic compounds, gallic acid (1), 3,5-di-O-galloylquinic acid (2), 1,6-di-O-galloyl glucopyranoside (3), 3,4,5-tri-O-galloylquinic acid (4), 1-O-eudesmoylquinic acid (5), 1,2,3,6-tetra-O-galloyl glucopyranoside (6), and 3,4,5-trimethoxyphenyl-(6'-O-galloyl)-O-b-D-glucopyranoside (7). The structure of the new compound 5 was established on the basis of interpretation of its 1D and 2D NMR spectroscopic data. Compounds 2, 3, 4, 6, and 7 showed weak inhibitory activity against the drug-sensitive HB3 and the drug-resistant FCM29 strains of P. falciparum, with IC (50) values ranging from 8.0 - 43.0 and 16.1 - 93.0 microg/mL, respectively.

Antiplasmodial activity of compounds from Sloanea rhodantha (Baker) Capuron var. rhodantha from the Madagascar rain forest. Publishing Authors By Initials

S Cao,L Ranarivelo,M Ratsimbason,S Randrianasolo,F Ratovoson,M Andrianjafy,DG Kingston,

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Antiplasmodial activity of compounds from Sloanea rhodantha (Baker) Capuron var. rhodantha from the Madagascar rain forest. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Planta medica

VOLUME: 72

Page Numbers: 1438-40

Journal Abbreviation: Planta Med.

ISSN: 0032-0943

DAY: 7

MONTH: 11

YEAR: 2006

Antiplasmodial activity of compounds from Sloanea rhodantha (Baker) Capuron var. rhodantha from the Madagascar rain forest. Information

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LANGUAGE: eng

NlmUniqueID: 66751

Antiplasmodial activity of compounds from Sloanea rhodantha (Baker) Capuron var. rhodantha from the Madagascar rain forest. Keywords Mesh Terms:

KEYWORDS: Trees

MESH TERMS: drug effects

Chemical & Substance for Abstract: Antiplasmodial activity of compounds from Sloanea rhodantha (Baker) Capuron var. rhodantha from the Madagascar rain forest. Information

Substance Name: Plant Extracts

Registry Number: 0

Grant and Affiliation Information for Antiplasmodial activity of compounds from Sloanea rhodantha (Baker) Capuron var. rhodantha from the Madagascar rain forest.

AFFILIATION: Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061-0212, USA.

Country: Germany

AGENCY: United States FIC

GRANT: U01 TW000313

ACRONYM: TW

MEDLINETA: Planta Med

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