Antiphospholipid antibodies and the antiphospholipid syndrome: pathogenic mechanisms.

Antiphospholipid antibodies and the antiphospholipid syndrome: pathogenic mechanisms. Research Abstract Details 

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Antiphospholipid antibodies and the antiphospholipid syndrome: pathogenic mechanisms. Abstract Text:

Antiphospholipid antibodies (Abs) are associated with thrombosis and are a risk factor for recurrent pregnancy loss and obstetric complications in patients with the antiphospholipid syndrome. It is generally accepted that the major autoantigen for aPL Abs is beta (2) glycoprotein I, which mediates the binding of aPL Abs to target cells (i.e., endothelial cells, monocytes, platelets, trophoblasts, etc.) leading to thrombosis and fetal loss. This article addresses molecular events triggered by aPL Abs on endothelial cells, platelets, and monocytes and complement activation, as well as a review of the current knowledge with regard to the putative receptor(s) recognized by aPL Abs on target cells as well as novel mechanisms that involve fibrinolytic processes. A section is devoted to the description of thrombotic and inflammatory processes that lead to obstetric complications mediated by aPL Abs. Based on experimental evidence using in vitro and in vivo models, new targeted therapies for treatment and/or prevention of thrombosis and pregnancy loss in antiphospholipid syndrome are proposed.

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Antiphospholipid antibodies and the antiphospholipid syndrome: pathogenic mechanisms. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Seminars in thrombosis and hemostasis

VOLUME: 34

Page Numbers: 236-50

Journal Abbreviation: Semin. Thromb. Hemost.

ISSN: 0094-6176

DAY: 22

MONTH: Apr

YEAR: 2008

Antiphospholipid antibodies and the antiphospholipid syndrome: pathogenic mechanisms. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Antiphospholipid antibodies and the antiphospholipid syndrome: pathogenic mechanisms.

AFFILIATION: Professor, Division of Rheumatology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas.

Country: United States

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MEDLINETA: Semin Thromb Hemost

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