Antiparkinson drugs used as prophylactics for nerve agents: Studies of cognitive side effects in rats.

Antiparkinson drugs used as prophylactics for nerve agents: Studies of cognitive side effects in rats. Research Abstract Details 

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Antiparkinson drugs used as prophylactics for nerve agents: Studies of cognitive side effects in rats. Abstract Text:

Antiparkinson agents possess excellent anticonvulsant properties against nerve agent-induced seizures by exerting both cholinergic and glutamatergic antagonisms. It is important, however, that drugs used as prophylactics not by themselves cause impairment of cognitive capability. The purpose of the present study was to make a comparative assessment of potential cognitive effects of benactyzine (0.3 mg/kg), biperiden (0.11 mg/kg), caramiphen (10 mg/kg), procyclidine (3 mg/kg), and trihexyphenidyl (0.12 mg/kg) separately and each in combination with physostigmine (0.1 mg/kg). The results showed that benactyzine, caramiphen, and trihexyphenidyl reduced rats' innate preference for novelty, whereas biperiden and procyclidine did not. When benactyzine, caramiphen, and trihexyphenidyl were combined with physostigmine the cognitive impairment disappeared. This counteracting effect, however, caused changes in locomotor and rearing activities not seen by each drug alone. Acetylcholinesterase inhibitors and anticholinergics used as prophylactics can offset each other, but exceptions are observed in a previous study when a very potent anticholinergic (scopolamine) or a high dose of procyclidine still results in cognitive deficits in spite of coadministration with physostigmine. Among the present drugs tested, procyclidine appears to be a robust anticonvulsant with few cognitive side effects.

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Antiparkinson drugs used as prophylactics for nerve agents: Studies of cognitive side effects in rats. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Pharmacology, biochemistry, and behavior

VOLUME: 89

Page Numbers: 633-8

Journal Abbreviation: Pharmacol. Biochem. Behav.

ISSN: 0091-3057

DAY: 7

MONTH: 03

YEAR: 2008

Antiparkinson drugs used as prophylactics for nerve agents: Studies of cognitive side effects in rats. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Antiparkinson drugs used as prophylactics for nerve agents: Studies of cognitive side effects in rats.

AFFILIATION: Norwegian Defence Research Establishment, Protection Division, Kjeller, Norway.

Country: United States

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MEDLINETA: Pharmacol Biochem Behav

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