Antioxidant therapy to prevent preeclampsia: a randomized controlled trial.

Antioxidant therapy to prevent preeclampsia: a randomized controlled trial. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Antioxidant therapy to prevent preeclampsia: a randomized controlled trial. Abstract Text:

Joseph A Spinnato,Salvio Freire,Joao Luiz Pinto E Silva,Marilza Vieira Cunha Rudge, Martins-Costa,Matthew A Koch,Norman Goco,Cleide de Barros Santos,Jose Guilherme Cecatti,Roberto Costa, Ramos,Nancy Moss,Baha M Sibai,Joseph A Spinnato,Salvio Freire,Joao Luiz Pinto E Silva,Marilza Vieira Cunha Rudge, Martins-Costa,Matthew A Koch,Norman Goco,Cleide de Barros Santos,Jose Guilherme Cecatti,Roberto Costa, Ramos,Nancy Moss,Baha M Sibai,

OBJECTIVE: To study whether antioxidant supplementation will reduce the incidence of preeclampsia among patients at increased risk. METHODS: A randomized, placebo-controlled, double-blind clinical trial was conducted at four Brazilian sites. Women between 12 0/7 weeks and 19 6/7 weeks of gestation and diagnosed to have chronic hypertension or a prior history of preeclampsia were randomly assigned to daily treatment with both vitamin C (1,000 mg) and vitamin E (400 International Units) or placebo. Analyses were adjusted for clinical site and risk group (prior preeclampsia, chronic hypertension, or both). A sample size of 734 would provide 80% power to detect a 40% reduction in the risk of preeclampsia, assuming a placebo group rate of 21% and alpha=.05. The alpha level for the final analysis, adjusted for interim looks, was 0.0458. RESULTS: Outcome data for 707 of 739 randomly assigned patients revealed no significant reduction in the rate of preeclampsia (study drug, 13.8% [49 of 355] compared with placebo, 15.6% [55 of 352], adjusted risk ratio 0.87 [95.42% confidence interval 0.61-1.25]). There were no differences in mean gestational age at delivery or rates of perinatal mortality, abruptio placentae, preterm delivery, and small for gestational age or low birth weight infants. Among patients without chronic hypertension, there was a slightly higher rate of severe preeclampsia in the study group (study drug, 6.5% [11 of 170] compared with placebo, 2.4% [4 of 168], exact P=.11, odds ratio 2.78, 95% confidence interval 0.79-12.62). CONCLUSION: This trial failed to demonstrate a benefit of antioxidant supplementation in reducing the rate of preeclampsia among patients with chronic hypertension and/or prior preeclampsia. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, www.ClinicalTrials.gov, NCT00097110 LEVEL OF EVIDENCE: I.

Antioxidant therapy to prevent preeclampsia: a randomized controlled trial. Publishing Authors By Initials

JA Spinnato,S Freire,JL Pinto E Silva,MV Cunha Rudge,S Martins-Costa,MA Koch,N Goco,Cde Santos,JG Cecatti,R Costa,JG Ramos,N Moss,BM Sibai,JA Spinnato,S Freire,JL Pinto E Silva,MV Cunha Rudge,S Martins-Costa,MA Koch,N Goco,Cde Santos,JG Cecatti,R Costa,JG Ramos,N Moss,BM Sibai,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Antioxidant therapy to prevent preeclampsia: a randomized controlled trial. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Obstetrics and gynecology

VOLUME: 110

Page Numbers: 1311-8

Journal Abbreviation:

ISSN: 0029-7844

DAY: 6

MONTH: Dec

YEAR: 2007

Antioxidant therapy to prevent preeclampsia: a randomized controlled trial. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 401101

Antioxidant therapy to prevent preeclampsia: a randomized controlled trial. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Antioxidant therapy to prevent preeclampsia: a randomized controlled trial. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Antioxidant therapy to prevent preeclampsia: a randomized controlled trial.

AFFILIATION: Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, Cincinnati, Ohio 40267-0526, USA. spinnaja@ucmail.uc.edu

Country: United States

AGENCY: United States NICHD

GRANT: 1 U01 HD40565

ACRONYM: HD

MEDLINETA: Obstet Gynecol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Antioxidant therapy to prevent preeclampsia: a randomized controlled trial Related Publications

• Acute fatty liver of pregnancy.
• Antioxidant therapy to prevent preeclampsia: a randomized controlled trial.
• Chronic hypertension in pregnancy.
• Duodeno-jejunal junction: a histoanatomical study with the concept of the existence of an "anatomical" sphincter.
• Electromyographic lag time and opening time: two novel noninvasive methods to investigate patients with anal outlet obstruction and their response to treatment.
• Expectant management of severe preeclampsia at less than 27 weeks' gestation: maternal and perinatal outcomes according to gestational age by weeks at onset of expectant management.
• HELLP syndrome: an atypical presentation.
• Hypertensive disorders of pregnancy: the United States perspective.
• Immediate post-operative vocal changes in patients using laryngeal mask airway versus endotracheal tube.
• Intergenerational factors: a missing link for preeclampsia, fetal growth restriction, and cardiovascular disease?
• Neonatal outcomes in pregnancies with preeclampsia or gestational hypertension and in normotensive pregnancies that delivered at 35, 36, or 37 weeks of gestation.
• Prediction and prevention of recurrent preeclampsia.
• Pregnancy outcome in isolated single umbilical artery.
• The coexistence of gestational hypertension and diabetes: influence on pregnancy outcome.
• The electromyographic activity of the external and internal urethral sphincters and urinary bladder on vaginal distension and its role in preventing vaginal soiling with urine during sexual intercourse.