Antineoplastic agents. 560. Isolation and structure of kitastatin 1 from an Alaskan Kitasatospora sp.

Antineoplastic agents. 560. Isolation and structure of kitastatin 1 from an Alaskan Kitasatospora sp. Research Abstract Details 

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Antineoplastic agents. 560. Isolation and structure of kitastatin 1 from an Alaskan Kitasatospora sp. Abstract Text:

George R Pettit,Rui Tan,Robin K Pettit,Thomas H Smith,Song Feng,Dennis L Doubek,Linda Richert,John Hamblin,Christine Weber,Jean-Charles Chapuis,

By utilizing a bioassay-guided separation (P388 lymphocytic leukemia and a panel of human cancer cell lines) of fermentation broths from a Kitasatospora sp. collected from a tundra soil sample taken at the shore of the Beaufort Sea, we have isolated three powerful (GI50 to 0.0006 microg/mL) cancer cell growth inhibitors (1-3) and determined their structures to be closely related cyclodepsipeptides. From 380 L fermentations of Kitasatospora sp. were obtained 2.6 mg of a new cyclodepsipeptide designated kitastatin 1 (3), accompanied by the previously known respirantin (1, 10.8 mg) and its valeryl homologue (2, 4.8 mg). The structures were determined by employment of a series of high-resolution mass and 2D NMR spectroscopic analyses. The stereochemical assignments and overall structures were confirmed by subsequent total synthesis of depsipeptide 1, as reported in the accompanying contribution.

Antineoplastic agents. 560. Isolation and structure of kitastatin 1 from an Alaskan Kitasatospora sp. Publishing Authors By Initials

GR Pettit,R Tan,RK Pettit,TH Smith,S Feng,DL Doubek,L Richert,J Hamblin,C Weber,JC Chapuis,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: molecular structure research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: molecular structure research

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Antineoplastic agents. 560. Isolation and structure of kitastatin 1 from an Alaskan Kitasatospora sp. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of natural products

VOLUME: 70

Page Numbers: 1069-72

Journal Abbreviation: J. Nat. Prod.

ISSN: 0163-3864

DAY: 4

MONTH: 07

YEAR: 2007

Antineoplastic agents. 560. Isolation and structure of kitastatin 1 from an Alaskan Kitasatospora sp. Information

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LANGUAGE: eng

NlmUniqueID: 7906882

Antineoplastic agents. 560. Isolation and structure of kitastatin 1 from an Alaskan Kitasatospora sp. Keywords Mesh Terms:

KEYWORDS: Molecular Structure

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Antineoplastic agents. 560. Isolation and structure of kitastatin 1 from an Alaskan Kitasatospora sp. Information

Substance Name: respirantin

Registry Number: 0

Grant and Affiliation Information for Antineoplastic agents. 560. Isolation and structure of kitastatin 1 from an Alaskan Kitasatospora sp.

AFFILIATION: Cancer Research Institute and Department of Chemistry and Biochemistry, Arizona State University, PO Box 872404, Tempe, Arizona 85287-2404, USA. bpettit@asu.edu

Country: United States

AGENCY: United States NCI

GRANT: R01CA90441-01-05

ACRONYM: CA

MEDLINETA: J Nat Prod

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