Antimitochondrial antibody-negative primary biliary cirrhosis.

Antimitochondrial antibody-negative primary biliary cirrhosis. Research Abstract Details 

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Antimitochondrial antibody-negative primary biliary cirrhosis. Abstract Text:

Primary biliary cirrhosis (PBC) is considered a classic autoimmune disease insofar as 95% of patients are seropositive for specific antimitochondrial antibodies (AMA). Yet it is still the case that the remaining 5% of patients have equivalent disease but test persistently AMA negative. Although variations exist in the immunologic profile of these patients, clinically there are no discernable differences, and although the diagnostic threshold is higher, the treatment and prognosis mirror that of classic disease. Previous terminology, therefore, has been abandoned in favor of the description, AMA-negative PBC.

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Antimitochondrial antibody-negative primary biliary cirrhosis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinics in liver disease

VOLUME: 12

Page Numbers: 323-31

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ISSN: 1089-3261

DAY: 5

MONTH: May

YEAR: 2008

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LANGUAGE: eng

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Grant and Affiliation Information for Antimitochondrial antibody-negative primary biliary cirrhosis.

AFFILIATION: Toronto Western Hospital, University Health Network, University of Toronto, 399 Bathurst Street, 6B Fell, Room 154, Toronto, Ontario M5T 2S8, Canada.

Country: United States

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MEDLINETA: Clin Liver Dis

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