Antimicrobial peptides in burns and wounds.

Antimicrobial peptides in burns and wounds. Research Abstract Details 

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Antimicrobial peptides in burns and wounds. Abstract Text:

Satyanarayan Bhat,Stephen Milner,Satyanarayan Bhat,Stephen Milner,

Burn-induced immunosuppression not only increases susceptibility to infection, but also predisposes burn patients to related adverse sequelae, including systemic inflammatory response syndrome and sepsis. Although burn-related immunosuppression is not fully understood, it is characterized by decreased T- and B-lymphocyte function and by impaired functions of circulating leukocytes and complement. Alterations in defensins, a family of cationic, naturally occurring antimicrobial peptides, may underlie these immune deficiency patterns. Defensins are considered important components of the innate immune system, as they inhibit bacterial, fungal, and viral colonization. They also chemoattract immature dendritic cells and T lymphocytes, recruit neutrophils, macrophages, and monocytes, modulate complement and adjuvant activity, and promote inflammation and wound healing. Infectious states are associated with upregulation of circulating defensins, which suggests an underlying antimicrobial role. In addition, data from our laboratory demonstrated diminished levels of certain defensins in burned tissue. The inference is that decreased defensin levels in burn injury may facilitate infection and subsequent sepsis. It may also alter functions of T- and B-lymphocytes, neutrophils, macrophages, and complement, thereby contributing to the pathophysiology of burn-related systemic inflammatory responses. This article is a comprehensive review on the role of antimicrobial peptides in burns and wounds.

Antimicrobial peptides in burns and wounds. Publishing Authors By Initials

S Bhat,S Milner,S Bhat,S Milner,

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Antimicrobial peptides in burns and wounds. Journal Published:

PUBLICATION TYPE: Review

Journal: Current protein & peptide science

VOLUME: 8

Page Numbers: 506-20

Journal Abbreviation: Curr. Protein Pept. Sci.

ISSN: 1389-2037

DAY: 5

MONTH: Oct

YEAR: 2007

Antimicrobial peptides in burns and wounds. Information

Number of References: 344

LANGUAGE: eng

NlmUniqueID: 100960529

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Grant and Affiliation Information for Antimicrobial peptides in burns and wounds.

AFFILIATION: Division of Burns and Michael D Hendrix Burn Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Country: Netherlands

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MEDLINETA: Curr Protein Pept Sci

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