Antileishmanial Compounds from Cordia fragrantissima Collected in Burma (Myanmar).

Antileishmanial Compounds from Cordia fragrantissima Collected in Burma (Myanmar). Research Abstract Details 

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Antileishmanial Compounds from Cordia fragrantissima Collected in Burma (Myanmar). Abstract Text:

Kanami Mori,Marii Kawano,Hiroyuki Fuchino,Takashi Ooi,Motoyoshi Satake,Yutaka Agatsuma,Takenori Kusumi,Setsuko Sekita,Kanami Mori,Marii Kawano,Hiroyuki Fuchino,Takashi Ooi,Motoyoshi Satake,Yutaka Agatsuma,Takenori Kusumi,Setsuko Sekita,

A methanol extract of the wood of Cordia fragrantissima, collected in Burma (Myanmar), was found to exhibit significant activity against Leishmania major. Bioassay-guided fractionation of this extract using several chromatographic techniques afforded three new compounds ( 1- 3) and five known compounds ( 4- 8). The structures of the new compounds were revealed on the basis of spectroscopic data interpretation and by X-ray crystallographic analysis. Interestingly, the new compounds, despite the presence of asymmetric carbons, were found to be racemates. The activities of the isolates from C. fragrantissima and several derivatives were evaluated against the promastigote forms of Leishmania major, L. panamensis, and L. guyanensis.

Antileishmanial Compounds from Cordia fragrantissima Collected in Burma (Myanmar). Publishing Authors By Initials

K Mori,M Kawano,H Fuchino,T Ooi,M Satake,Y Agatsuma,T Kusumi,S Sekita,K Mori,M Kawano,H Fuchino,T Ooi,M Satake,Y Agatsuma,T Kusumi,S Sekita,

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Antileishmanial Compounds from Cordia fragrantissima Collected in Burma (Myanmar). Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of natural products

VOLUME: 71

Page Numbers: 18-21

Journal Abbreviation: J. Nat. Prod.

ISSN: 0163-3864

DAY: 19

MONTH: 12

YEAR: 2007

Antileishmanial Compounds from Cordia fragrantissima Collected in Burma (Myanmar). Information

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LANGUAGE: eng

NlmUniqueID: 7906882

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AFFILIATION: sekita@kph.bunri-u.ac.jp.

Country: United States

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MEDLINETA: J Nat Prod

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