Antiinflammatory activities of Rubus coreanus depend on the degree of fruit ripening.

Antiinflammatory activities of Rubus coreanus depend on the degree of fruit ripening. Research Abstract Details 

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Antiinflammatory activities of Rubus coreanus depend on the degree of fruit ripening. Abstract Text:

Hyun Mo Yang,Sun-Mee Oh,Soon Sung Lim,Hyun-Kyung Shin,Yang-Seok Oh,Jin-Kyung Kim,Hyun Mo Yang,Sun-mee Oh,Soon Sung Lim,Hyun-Kyung Shin,Yang-Seok Oh,Jin-Kyung Kim,

The dried unripe fruit of Rubus coreanus, which is well-known in Korea and referred to as 'Bok-bun-ja', has been employed as a traditional medicine for centuries. This crude drug is utilized in Korea for the management of impotence, spermatorrhea, enuresis, asthma and allergic diseases. The principal objective of the present study was to conduct a comparison of the antiinflammatory effects of ethanol extracts of the unripe (URCE), half-ripened (HRCE) and ripe fruits (RCE) of Rubus coreanus. URCE and HRCE were found to reduce the production of nitric oxide (NO) and prostaglandin E(2) (PGE(2)) as well as pro-inflammatory cytokines, in lipopolysaccharide (LPS)-stimulated RAW264.7 murine macrophages. However, RCE exerted no inhibitory effects against the production of NO and IL-6. The results of the study show that the degree of fruit ripening of Rubus coreanus affects the production of inflammatory mediators such as NO, PGE(2) and inflammatory cytokines. Copyright (c) 2007 John Wiley & Sons, Ltd.

Antiinflammatory activities of Rubus coreanus depend on the degree of fruit ripening. Publishing Authors By Initials

HM Yang,SM Oh,SS Lim,HK Shin,YS Oh,JK Kim,HM Yang,SM Oh,SS Lim,HK Shin,YS Oh,JK Kim,

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Antiinflammatory activities of Rubus coreanus depend on the degree of fruit ripening. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Phytotherapy research : PTR

VOLUME: 22

Page Numbers: 102-7

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ISSN: 0951-418X

DAY: 3

MONTH: Jan

YEAR: 2008

Antiinflammatory activities of Rubus coreanus depend on the degree of fruit ripening. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Antiinflammatory activities of Rubus coreanus depend on the degree of fruit ripening.

AFFILIATION: Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University, Gangwon-do 200-702, Korea.

Country: England

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MEDLINETA: Phytother Res

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