Antihepatotoxic Actions of Allium sativum Bulbs1.

Antihepatotoxic Actions of Allium sativum Bulbs1. Research Abstract Details 

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Antihepatotoxic Actions of Allium sativum Bulbs1. Abstract Text:

H Hikino,M Tohkin,Y Kiso,T Namiki,S Nishimura,K Takeyama,

Garlic constituents, the volatile oil, alliin, S-allylmercaptocysteine (ASSC) and S-methylmercapto-cysteine (MSSC) were subjected to assay for their antihepatotoxic activity using the IN VITRO and IN VIVO liver damage models. Marked inhibitory activity was found with the volatile oil, ASSC and MSSC in carbon tetrachloride (CCl (4))- and galactosamine (GalN)-induced cytotoxicity in primary cultured rat hepatocytes as model systems. ASSC exhibited a remarkable inhibitory action and the volatile oil, alliin and MSSC showed tendencies to elicit protective actions in GalN-produced liver lesion in rats. The volatile oil inhibited CCl (4)-induced free radical formation and lipid peroxidation, indicating that anti-oxidative activity participates in the inhibitory effect of the volatile oil in CCl (4)-evoked liver damage.

Antihepatotoxic Actions of Allium sativum Bulbs1. Publishing Authors By Initials

H Hikino,M Tohkin,Y Kiso,T Namiki,S Nishimura,K Takeyama,

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Antihepatotoxic Actions of Allium sativum Bulbs1. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Planta medica

VOLUME: 52

Page Numbers: 163-8

Journal Abbreviation: Planta Med.

ISSN: 0032-0943

DAY: 8

MONTH: Jun

YEAR: 1986

Antihepatotoxic Actions of Allium sativum Bulbs1. Information

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LANGUAGE: eng

NlmUniqueID: 66751

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Grant and Affiliation Information for Antihepatotoxic Actions of Allium sativum Bulbs1.

AFFILIATION: Pharmaceutical Institute, Tohoku University, Aoba-yama, Sendai 980, Japan.

Country: Germany

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MEDLINETA: Planta Med

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