Antigenicity and recombination of VlsE, the antigenic variation protein of Borrelia burgdorferi, in rabbits, a host putatively resistant to long-term infection with this spirochete.

Antigenicity and recombination of VlsE, the antigenic variation protein of Borrelia burgdorferi, in rabbits, a host putatively resistant to long-term infection with this spirochete. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Antigenicity and recombination of VlsE, the antigenic variation protein of Borrelia burgdorferi, in rabbits, a host putatively resistant to long-term infection with this spirochete. Abstract Text:

Monica E Embers,Fang Ting Liang,Jerrilyn K Howell,Mary B Jacobs,Jeanette E Purcell,Steven J Norris,Barbara J B Johnson,Mario T Philipp,

Borrelia burgdorferi, the Lyme disease pathogen, employs several immune-evasive strategies to survive in mammals. Unlike mice, major reservoir hosts for B. burgdorferi, rabbits are considered to be nonpermissive hosts for persistent infection. Antigenic variation of the VlsE molecule is a probable evasion strategy known to function in mice. The invariable region 6 (IR6) and carboxyl-terminal domain (Ct) of VlsE elicit dominant antibody responses that are not protective, perhaps to function as decoy epitopes that protect the spirochete. We sought to determine if either of these characteristics of VlsE differed in rabbit infection, contributing to its reputed nonpermissiveness. VlsE recombination was observed in rabbits that were given inoculations with either cultured or host-adapted spirochetes. Early observations showed a lack of anti-C6 (a peptide encompassing the IR6 region) response in most rabbits, so the anti-Ct and anti-C6 responses were monitored for 98 weeks. Anti-C6 antibody appeared as late as 20 weeks postinoculation, and the anti-Ct response, evident within the first 2 weeks, oscillated for prolonged periods of time. These observations, together with the recovery of cultivable spirochetes from tissue of one animal at 98 weeks postinoculation, challenge the notion that the rabbit cannot harbour a long-term B. burgdorferi infection.

Antigenicity and recombination of VlsE, the antigenic variation protein of Borrelia burgdorferi, in rabbits, a host putatively resistant to long-term infection with this spirochete. Publishing Authors By Initials

ME Embers,FT Liang,JK Howell,MB Jacobs,JE Purcell,SJ Norris,BJ Johnson,MT Philipp,

For similar genetic processes: recombination, genetic research abstracts see: genetic processes: recombination, genetic research

PUBMED ID PMID:

MEDLINE DATE:

Antigenicity and recombination of VlsE, the antigenic variation protein of Borrelia burgdorferi, in rabbits, a host putatively resistant to long-term infection with this spirochete. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: FEMS immunology and medical microbiology

VOLUME: 50

Page Numbers: 421-9

Journal Abbreviation: FEMS Immunol. Med. Microbiol.

ISSN: 0928-8244

DAY: 26

MONTH: 06

YEAR: 2007

Antigenicity and recombination of VlsE, the antigenic variation protein of Borrelia burgdorferi, in rabbits, a host putatively resistant to long-term infection with this spirochete. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9315554

Antigenicity and recombination of VlsE, the antigenic variation protein of Borrelia burgdorferi, in rabbits, a host putatively resistant to long-term infection with this spirochete. Keywords Mesh Terms:

KEYWORDS: Recombination, Genetic

MESH TERMS: microbiology

Chemical & Substance for Abstract: Antigenicity and recombination of VlsE, the antigenic variation protein of Borrelia burgdorferi, in rabbits, a host putatively resistant to long-term infection with this spirochete. Information

Substance Name: VlsE protein, Borrelia burgdorferi

Registry Number: 0

Grant and Affiliation Information for Antigenicity and recombination of VlsE, the antigenic variation protein of Borrelia burgdorferi, in rabbits, a host putatively resistant to long-term infection with this spirochete.

AFFILIATION: Division of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, LA 70433, USA.

Country: England

AGENCY: United States NCRR

GRANT: RR00164-41

ACRONYM: RR

MEDLINETA: FEMS Immunol Med Microbiol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Antigenicity and recombination of VlsE, the antigenic variation protein of Borrelia burgdorferi, in rabbits, a host putatively resistant to long-term infection with this spirochete Related Publications

• Absence of an association of tumor necrosis factor (TNF)-alpha G308A, interleukin-6 (IL-6) G174C and interleukin-10 (IL-10) G1082A polymorphism in women with preeclampsia.
• Antigenicity and recombination of VlsE, the antigenic variation protein of Borrelia burgdorferi, in rabbits, a host putatively resistant to long-term infection with this spirochete.
• Biochemical and genetic investigation of initial reactions in aerobic degradation of the bile acid cholate in Pseudomonas sp. strain Chol1.
• Borrelia burgdorferi spirochetes that harbor only a portion of the lp28-1 plasmid elicit antibody responses detectable with the C6 test for Lyme disease.
• Dominant epitopes of the C6 diagnostic peptide of Borrelia burgdorferi are largely inaccessible to antibody on the parent VlsE molecule.
• Effects of incremental increases in silt load on the cardiovascular performance of riverine and lacustrine rock bass, Ambloplites rupestris.
• Enhancement of local species richness in tundra by seed dispersal through guts of muskox and barnacle goose.
• Hereditary (familial) spastic paraplegia; report of six cases in one family.
• Images in clinical medicine. High-resolution imaging of myocardial bridging.
• Interleukin-10 anti-inflammatory response to Borrelia burgdorferi, the agent of Lyme disease: a possible role for suppressors of cytokine signaling 1 and 3.
• The murine gene Cdkn1b (p27(Kip1)) maps to distal chromosome 6 and is excluded as Pas1.
• The relief of the pain of childbirth.
• [An instrument to facilitate the preparation of cytological samples]
• [Carcinoma of cervix in pregnancy (author's transl)]
• [Case contribution on ovarian carcinoma in monovular twins]
• [Case report on the morphological and clinical aspects of hidradenoma vulvae]
• [Change in placental polypi therapy.]
• [Diagnosis and therapy of 36 alleged early forms of cervical carcinoma in pregnancy (author's transl)]
• [Electron microscopy for examination of epithelium of hydrosalpinx (author's transl)]
• [Electron microscopy studies on the early development of the endocervical epithelium in human fetuses]
• [Further electron microscopy studies on early development of endocervical epithelium in human fetuses]
• [Modified measurement of placental blood flow at I Gynaecological Hospital of Vienna University (author's transl)]
• [New aspiration technique in gynaecology (author's transl)]
• [New non-traumatic vacuum adapter with vaginal cylinder for hysterosalpingography (author's transl)]
• [Not Available.]
• [Our gynecologic heritage. Placental gonadotropin, estrogens and progesterone. The research of Ernst Philipp in the history of gynecologic endocrinology]
• [Progress in radio-isotope surgery for cervical carcinoma (author's transl)]
• [Roentgenography of functional changes of the uterus.]
• [Transformation of secretory cylindrial cells into ciliar cells in the epithelium of the human uterine cervix (functional transformation of highly differentiated cells)]
• [Ultramicroscopic studies on the drainage system of the human corpus luteum]