Antigenic targeting of the human mannose receptor induces tumor immunity.

Antigenic targeting of the human mannose receptor induces tumor immunity. Research Abstract Details 

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Antigenic targeting of the human mannose receptor induces tumor immunity. Abstract Text:

Li-Zhen He,Andrea Crocker,Janine Lee,Jose Mendoza-Ramirez,Xi-Tao Wang,Laura A Vitale,Thomas O'Neill,Chris Petromilli,Hui-Fen Zhang,Joe Lopez,Dan Rohrer,Tibor Keler,Raphael Clynes,

Pattern recognition receptors are preferentially expressed on APCs allowing selective uptake of pathogens for the initiation of antimicrobial immunity. In particular, C-type lectin receptors, including the mannose receptor (MR), facilitate APC-mediated adsorptive endocytosis of microbial glyconjugates. We have investigated the potential of antigenic targeting to the MR as a means to induce Ag-specific humoral and cellular immunity. hMR transgenic (hMR Tg) mice were generated to allow specific targeting with the anti-hMR Ab, B11. We show that hMR targeting induced both humoral and cellular antigenic specific immunity. Immunization of hMR Tg mice with B11 mAbs induced potent humoral responses independent of adjuvant. Injection of hMR Tg mice with mouse anti-hMR Ab clone 19.2 elicited anti-Id-specific humoral immunity while non-Tg mice were unresponsive. B11-OVA fusion proteins (B11-OVA) were efficiently presented to OVA-specific CD4 and CD8 T cells in MR Tg, but not in non-Tg, mice. Effector differentiation of responding T cells in MR Tg mice was significantly enhanced with concomitant immunization with the TLR agonist, CpG. Administration of both CpG and B11-OVA to hMR Tg mice induced OVA-specific tumor immunity while WT mice remained unprotected. These studies support the clinical development of immunotherapeutic approaches in cancer using pattern recognition receptor targeting systems for the selective delivery of tumor Ags to APCs.

Antigenic targeting of the human mannose receptor induces tumor immunity. Publishing Authors By Initials

LZ He,A Crocker,J Lee,J Mendoza-Ramirez,XT Wang,LA Vitale,T O'Neill,C Petromilli,HF Zhang,J Lopez,D Rohrer,T Keler,R Clynes,

For similar proteins: membrane proteins: receptors, cell surface research abstracts see: proteins: membrane proteins: receptors, cell surface research

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MEDLINE DATE:

Antigenic targeting of the human mannose receptor induces tumor immunity. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of immunology (Baltimore, Md. : 1950)

VOLUME: 178

Page Numbers: 6259-67

Journal Abbreviation:

ISSN: 0022-1767

DAY: 15

MONTH: May

YEAR: 2007

Antigenic targeting of the human mannose receptor induces tumor immunity. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985117

Antigenic targeting of the human mannose receptor induces tumor immunity. Keywords Mesh Terms:

KEYWORDS: Receptors, Cell Surface

MESH TERMS: metabolism

Chemical & Substance for Abstract: Antigenic targeting of the human mannose receptor induces tumor immunity. Information

Substance Name: Insulin-Like Growth Factor II

Registry Number: 67763-97-7

Grant and Affiliation Information for Antigenic targeting of the human mannose receptor induces tumor immunity.

AFFILIATION: Celldex Therapeutics, Bloomsbury, NJ 08804, USA.

Country: United States

AGENCY: United States NCI

GRANT: R01 CA94037

ACRONYM: CA

MEDLINETA: J Immunol

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