Antigen three-dimensional structure guides the processing and presentation of helper T-cell epitopes.

Antigen three-dimensional structure guides the processing and presentation of helper T-cell epitopes. Research Abstract Details 

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Antigen three-dimensional structure guides the processing and presentation of helper T-cell epitopes. Abstract Text:

Stephanie Carmicle,N Kalaya Steede,Samuel J Landry,

Antigen three-dimensional structure potentially controls presentation of CD4(+) T-cell epitopes by limiting the access of proteolytic enzymes and MHC class II antigen-presenting proteins. The protease-sensitive mobile loops of Hsp10s from mycobacteria, Escherichia coli, and bacteriophage T4 (T4Hsp10) are associated with adjacent immunodominant helper T-cell epitopes, and a mobile-loop deletion in T4Hsp10 eliminated the protease sensitivity and the associated epitope immunodominance. In the present work, protease-sensitivity and epitope presentation was analyzed in a group of T4Hsp10 variants. Two mobile-loop sequence variants of T4Hsp10 were constructed by replacing different segments of the mobile loop with an irrelevant sequence from hen egg lysozyme. The variant proteins retained native-like structure, and the mobile loops retained protease sensitivity. Mobile-loop deletion and reconstruction affected the presentation of two epitopes according to whether the epitope was protease-independent or protease-dependent. The protease-independent epitope lies within the mobile loop, and the protease-dependent epitope lies in a well-ordered segment on the carboxy-terminal flank of the mobile loop. The results are consistent with a model for processing of the protease-dependent epitope in which an endoproteolytic nick in the mobile-loop unlocks T4Hsp10 three-dimensional structure, and then the epitope becomes available for binding to the MHC protein.

Antigen three-dimensional structure guides the processing and presentation of helper T-cell epitopes. Publishing Authors By Initials

S Carmicle,NK Steede,SJ Landry,

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Antigen three-dimensional structure guides the processing and presentation of helper T-cell epitopes. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Molecular immunology

VOLUME: 44

Page Numbers: 1159-68

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ISSN: 0161-5890

DAY: 8

MONTH: 08

YEAR: 2006

Antigen three-dimensional structure guides the processing and presentation of helper T-cell epitopes. Information

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LANGUAGE: eng

NlmUniqueID: 7905289

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Grant and Affiliation Information for Antigen three-dimensional structure guides the processing and presentation of helper T-cell epitopes.

AFFILIATION: Department of Biochemistry, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA.

Country: England

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MEDLINETA: Mol Immunol

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