Antigen-specific precursor frequency impacts T cell proliferation, differentiation, and requirement for costimulation.

Antigen-specific precursor frequency impacts T cell proliferation, differentiation, and requirement for costimulation. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Antigen-specific precursor frequency impacts T cell proliferation, differentiation, and requirement for costimulation. Abstract Text:

Mandy L Ford,Brent H Koehn,Maylene E Wagener,Wanhong Jiang,Shivaprakash Gangappa,Thomas C Pearson,Christian P Larsen,

After a brief period of antigenic stimulation, T cells become committed to a program of autonomous expansion and differentiation. We investigated the role of antigen-specific T cell precursor frequency as a possible cell-extrinsic factor impacting T cell programming in a model of allogeneic tissue transplantation. Using an adoptive transfer system to incrementally raise the precursor frequency of antigen-specific CD8(+) T cells, we found that donor-reactive T cells primed at low frequency exhibited increased cellular division, decreased development of multifunctional effector activity, and an increased requirement for CD28- and CD154-mediated costimulation relative to those primed at high frequency. The results demonstrated that recipients with low CD4(+) and CD8(+) donor-reactive T cell frequencies exhibited long-term skin graft survival upon CD28/CD154 blockade, whereas simultaneously raising the frequency of CD4(+) T cells to approximately 0.5% and CD8(+) T cells to approximately 5% precipitated graft rejection despite CD28/CD154 blockade. Antigenic rechallenge of equal numbers of cells stimulated at high or low frequency revealed that cells retained an imprint of the frequency at which they were primed. These results demonstrate a critical role for initial precursor frequency in determining the CD8(+) T cell requirement for CD28- and CD154-mediated costimulatory signals during graft rejection.

Antigen-specific precursor frequency impacts T cell proliferation, differentiation, and requirement for costimulation. Publishing Authors By Initials

ML Ford,BH Koehn,ME Wagener,W Jiang,S Gangappa,TC Pearson,CP Larsen,

For similar surgical procedures, operative: transplantation: transplantation, homologous research abstracts see: surgical procedures, operative: transplantation: transplantation, homologous research

PUBMED ID PMID:

MEDLINE DATE:

Antigen-specific precursor frequency impacts T cell proliferation, differentiation, and requirement for costimulation. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of experimental medicine

VOLUME: 204

Page Numbers: 299-309

Journal Abbreviation: J. Exp. Med.

ISSN: 0022-1007

DAY: 29

MONTH: 01

YEAR: 2007

Antigen-specific precursor frequency impacts T cell proliferation, differentiation, and requirement for costimulation. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985109

Antigen-specific precursor frequency impacts T cell proliferation, differentiation, and requirement for costimulation. Keywords Mesh Terms:

KEYWORDS: Transplantation, Homologous

MESH TERMS: immunology

Chemical & Substance for Abstract: Antigen-specific precursor frequency impacts T cell proliferation, differentiation, and requirement for costimulation. Information

Substance Name: CD40 Ligand

Registry Number: 147205-72-9

Grant and Affiliation Information for Antigen-specific precursor frequency impacts T cell proliferation, differentiation, and requirement for costimulation.

AFFILIATION: Department of Surgery and Emory Transplant Center, Emory University, Atlanta, GA 30322, USA.

Country: United States

AGENCY: United States NIAID

GRANT: AI04464

ACRONYM: AI

MEDLINETA: J Exp Med

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Antigen-specific precursor frequency impacts T cell proliferation, differentiation, and requirement for costimulation Related Publications

• 'Stories from the past, the reality of the present, taking control of the future'--lifestyle changes among Pukapuka people in the Illawarra.
• A Community-based study of risk factors for Trichomonas vaginalis infection among women and their male partners in Moshi urban district, northern Tanzania.
• A new spectrophotometric method for the selective determination of ampicillin, amoxycillin and cyclacillin in the presence of polymers and other degradation products.
• A path algorithm for the support vector domain description and its application to medical imaging.
• Antigen-specific precursor frequency impacts T cell proliferation, differentiation, and requirement for costimulation.
• Antigenic disparity impacts outcome of agonism but not blockade of costimulatory pathways in experimental transplant models.
• Arabidopsis enhanced ethylene response 4 encodes an EIN3-interacting TFIID transcription factor required for proper ethylene response, including ERF1 induction.
• Behavioral and neural responses of toads to salt solutions correlate with basolateral membrane potential of epidermal cells of the skin.
• Cell-mediated immunity in anorexia nervosa augmented lymphocyte transformation response to concanavalin A and lack of increased risk of infection.
• Cognitive functioning in healthy aging: the role of reserve and lifestyle factors early in life.
• Comparison of coagulant activity of factor VII and activated factor VII activity assays when used for determination of recombinant activated factor VII levels in plasma.
• Comparison of terlipressin and noradrenalin on cerebral perfusion, intracranial pressure and cerebral extracellular concentrations of lactate and pyruvate in patients with acute liver failure in need of inotropic support.
• Design of histidine containing peptides for better understanding of their coordination mode toward copper(II) by CD spectroscopy.
• Diagnosis and treatment of chronic T-lymphocytic leukemia in a spotted hyena (Crocuta crocuta).
• Differences in the characteristics of induced and spontaneous episodes of ventricular fibrillation.
• Early discontinuation: more frequent among general practitioners with high levels of prescribing.
• Engraftment of adult porcine islet xenografts in diabetic nonhuman primates through targeting of costimulation pathways.
• Evidence for fast conformational change upon ligand dissociation in the HemAT class of bacterial oxygen sensors.
• Fully MHC-disparate mixed hemopoietic chimeras show specific defects in the control of chronic viral infections.
• Hepatitis-C prevalence in an urban native-American clinic: a prospective screening study.
• Induction of chimerism in rhesus macaques through stem cell transplant and costimulation blockade-based immunosuppression.
• Influence of air intake on the concentration of free fatty acids and vacuum fluctuations during automatic milking.
• Motherhood status and union formation in Moshi, Tanzania 2002-2003.
• Pharmacokinetic modelling of blood-brain barrier transport of escitalopram in rats.
• Prioritisation of telemedicine services for large scale implementation in Norway.
• Targeted cancer therapy with a novel low-dose rate alpha-emitting radioimmunoconjugate.
• The search for viruses in bovine semen, a review.
• TonB/TolA Amino-Terminal Domain Modeling.
• Vertical transmission of bovine viral diarrhoea virus (BVDV) in mousedeer (Tragulus javanicus) and spread to domestic cattle.
• Veterinary obstetrics and genital diseases (Theriogenology) by S.J. Roberts (ed.); 981 pages, $72.00. 1986, 3rd edition. Published by the author, Woodstock, VT 05091. Distributed by David and Charles Inc., North Pomfret, VT 05053.