Antigen-specific CD8+ T cell clonal expansions develop from memory T cell pools established by acute respiratory virus infections.

Antigen-specific CD8+ T cell clonal expansions develop from memory T cell pools established by acute respiratory virus infections. Research Abstract Details 

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Antigen-specific CD8+ T cell clonal expansions develop from memory T cell pools established by acute respiratory virus infections. Abstract Text:

Kenneth H Ely,Mushtaq Ahmed,Jacob E Kohlmeier,Alan D Roberts,Susan T Wittmer,Marcia A Blackman,David L Woodland,

Increasing age is associated with the development of CD8+ T cell clonal expansions (TCE) that can dominate the peripheral T cell repertoire and interfere with immune responses to infection and vaccination. Some TCE are driven by chronic infections, consistent with dysregulated outgrowth of T cell clones in response to persistent antigenic stimulation. However, a second class of TCE develops with age in the absence of chronic infections and is poorly understood in terms of origin or Ag dependence. In this study, we present evidence that Ag-specific TCE develop at high frequencies from conventional memory CD8+ T cell pools elicited by nonpersistent influenza and parainfluenza virus infections. Putative TCE occurred in both the central- and effector-memory CD8+ T cell populations and did not require Ag for their maintenance. In addition, they were similar to normal memory T cells in terms of phenotype and function, suggesting that they develop stochastically from the memory T cell pool. These data suggest that memory T cell pools become progressively dysregulated over time and this may have a significant impact on immune responsiveness in the aged.

Antigen-specific CD8+ T cell clonal expansions develop from memory T cell pools established by acute respiratory virus infections. Publishing Authors By Initials

KH Ely,M Ahmed,JE Kohlmeier,AD Roberts,ST Wittmer,MA Blackman,DL Woodland,

For similar cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: lymphocyte subsets: t-lymphocyte subsets research abstracts see: cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: lymphocyte subsets: t-lymphocyte subsets research

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Antigen-specific CD8+ T cell clonal expansions develop from memory T cell pools established by acute respiratory virus infections. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of immunology (Baltimore, Md. : 1950)

VOLUME: 179

Page Numbers: 3535-42

Journal Abbreviation: J. Immunol.

ISSN: 0022-1767

DAY: 15

MONTH: Sep

YEAR: 2007

Antigen-specific CD8+ T cell clonal expansions develop from memory T cell pools established by acute respiratory virus infections. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985117

Antigen-specific CD8+ T cell clonal expansions develop from memory T cell pools established by acute respiratory virus infections. Keywords Mesh Terms:

KEYWORDS: T-Lymphocyte Subsets

MESH TERMS: virology

Chemical & Substance for Abstract: Antigen-specific CD8+ T cell clonal expansions develop from memory T cell pools established by acute respiratory virus infections. Information

Substance Name: Receptors, Antigen, T-Cell, alpha-beta

Registry Number: 0

Grant and Affiliation Information for Antigen-specific CD8+ T cell clonal expansions develop from memory T cell pools established by acute respiratory virus infections.

AFFILIATION: Trudeau Institute, Saranac Lake, NY 12983, USA.

Country: United States

AGENCY: United States NIAID

GRANT: AI49823

ACRONYM: AI

MEDLINETA: J Immunol

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