Antigen kinetics determines immune reactivity.

Antigen kinetics determines immune reactivity. Research Abstract Details 

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Antigen kinetics determines immune reactivity. Abstract Text:

Johansen,Tazio Storni,Lorna Rettig,Zhiyong Qiu,Ani Der-Sarkissian,Kent A Smith,Vania Manolova,Karl S Lang,Gabriela Senti,Beat ,Tilman Gerlach,Roberto F Speck,Adrian Bot,Thomas M , Johansen,Tazio Storni,Lorna Rettig,Zhiyong Qiu,Ani Der-Sarkissian,Kent A Smith,Vania Manolova,Karl S Lang,Gabriela Senti,Beat ,Tilman Gerlach,Roberto F Speck,Adrian Bot,Thomas M ,

A current paradigm in immunology is that the strength of T cell responses is governed by antigen dose, localization, and costimulatory signals. This study investigates the influence of antigen kinetics on CD8 T cell responses in mice. A fixed cumulative antigen dose was administered by different schedules to produce distinct dose-kinetics. Antigenic stimulation increasing exponentially over days was a stronger stimulus for CD8 T cells and antiviral immunity than a single dose or multiple dosing with daily equal doses. The same was observed for dendritic cell vaccination, with regard to T cell and anti-tumor responses, and for T cells stimulated in vitro. In conclusion, stimulation kinetics per se was shown to be a separate parameter of immunogenicity. These findings warrant a revision of current immunization models and have implications for vaccine development and immunotherapy.

Antigen kinetics determines immune reactivity. Publishing Authors By Initials

P Johansen,T Storni,L Rettig,Z Qiu,A Der-Sarkissian,KA Smith,V Manolova,KS Lang,G Senti,B ,T Gerlach,RF Speck,A Bot,TM ,P Johansen,T Storni,L Rettig,Z Qiu,A Der-Sarkissian,KA Smith,V Manolova,KS Lang,G Senti,B ,T Gerlach,RF Speck,A Bot,TM ,

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Antigen kinetics determines immune reactivity. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 105

Page Numbers: 5189-94

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 1091-6490

DAY: 24

MONTH: 03

YEAR: 2008

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LANGUAGE: eng

NlmUniqueID: 7505876

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Grant and Affiliation Information for Antigen kinetics determines immune reactivity.

AFFILIATION: Unit Experimental Immunotherapy, Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, CH-8091 Zurich, Switzerland.

Country: United States

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MEDLINETA: Proc Natl Acad Sci U S A

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