Antifungal therapy--state of the art at the beginning of the 21st century.

Antifungal therapy--state of the art at the beginning of the 21st century. Research Abstract Details 

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Antifungal therapy--state of the art at the beginning of the 21st century. Abstract Text:

The most relevant information on the present state of the art of antifungal chemotherapy is reviewed in this chapter. For dermatomycoses a variety of topical antifungals are available, and safe and efficacious systemic treatment, especially with the fungicidal drug terbinafine, is possible. The duration of treatment can be drastically reduced. Substantial progress in the armamentarium of drugs for invasive fungal infections has been made, and a new class of antifungals, echinocandins, is now in clinical use. The following drugs in oral and/or intravenous formulations are available: the broad spectrum polyene amphotericin B with its new "clothes"; the sterol biosynthesis inhibitors fluconazole, itraconazole, and voriconazole; the glucan synthase inhibitor caspofungin; and the combination partner flucytosine. New therapy schedules have been studied; combination therapy has found a significant place in the treatment of severely compromised patients, and the field of prevention and empiric therapy is fast moving. Guidelines exist nowadays for the treatment of various fungal diseases and maintenance therapy. New approaches interfering with host defenses or pathogenicity of fungal cells are being investigated, and molecular biologists are looking for new targets studying the genomics of pathogenic fungi.

Antifungal therapy--state of the art at the beginning of the 21st century. Publishing Authors By Initials

For similar bacterial infections and mycoses: mycoses research abstracts see: bacterial infections and mycoses: mycoses research

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Antifungal therapy--state of the art at the beginning of the 21st century. Journal Published:

PUBLICATION TYPE: Review

Journal: Progress in drug research. Fortschritte der Arznei

VOLUME: Spec No

Page Numbers: 59-190

Journal Abbreviation:

ISSN: 0071-786X

DAY: 25

MONTH: 02

YEAR: 2003

Antifungal therapy--state of the art at the beginning of the 21st century. Information

Number of References: 679

LANGUAGE: eng

NlmUniqueID: 1304021

Antifungal therapy--state of the art at the beginning of the 21st century. Keywords Mesh Terms:

KEYWORDS: Mycoses

MESH TERMS: pathology

Chemical & Substance for Abstract: Antifungal therapy--state of the art at the beginning of the 21st century. Information

Substance Name: Antifungal Agents

Registry Number: 0

Grant and Affiliation Information for Antifungal therapy--state of the art at the beginning of the 21st century.

AFFILIATION: Spitzenrainweg 45, CH-4147 Aesch, Switzerland.

Country: Switzerland

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MEDLINETA: Prog Drug Res

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