Antidepressants in long-term therapy: a review of tricyclic antidepressants and selective serotonin reuptake inhibitors.

Antidepressants in long-term therapy: a review of tricyclic antidepressants and selective serotonin reuptake inhibitors. Research Abstract Details 

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Antidepressants in long-term therapy: a review of tricyclic antidepressants and selective serotonin reuptake inhibitors. Abstract Text:

R M Hirschfeld,

OBJECTIVE: Although depression has been shown to be a long-term disorder, most research studies have concentrated on its acute treatment. METHOD: A literature review of the use of tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs) in long-term treatment of depression was performed and recommendations regarding long-term treatment were summarized. RESULTS: Studies conclusively document the need for continuation treatment after initial remission of symptoms to prevent relapse. Studies also suggest that continuation treatment should last a minimum of 3-6 months following acute response. Conclusions from a few maintenance studies clearly show that recurrence rates are lower when patients at risk for recurrence continue their active treatment at its original dose than when they are switched to placebo. CONCLUSION: Overall, studies conclude that depression is a recurrent, often chronic, lifetime illness requiring long-term treatment. Continuation therapy of 3 to 6 months after acute stabilization should be considered standard for all depressed patients, and maintenance therapy should be considered for many depressed patients. Newer agents, such as the SSRIs, are preferable to the TCAs for long-term treatment based on their superior tolerability and safety. However, because of the limited number of maintenance studies, further studies using a prospective, randomized design are needed to address this issue.

Antidepressants in long-term therapy: a review of tricyclic antidepressants and selective serotonin reuptake inhibitors. Publishing Authors By Initials

RM Hirschfeld,

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

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Antidepressants in long-term therapy: a review of tricyclic antidepressants and selective serotonin reuptake inhibitors. Journal Published:

PUBLICATION TYPE: Review

Journal: Acta psychiatrica Scandinavica. Supplementum

VOLUME: 403

Page Numbers: 35-8

Journal Abbreviation:

ISSN: 0065-1591

DAY: 15

MONTH: 02

YEAR: 2000

Antidepressants in long-term therapy: a review of tricyclic antidepressants and selective serotonin reuptake inhibitors. Information

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LANGUAGE: eng

NlmUniqueID: 370365

Antidepressants in long-term therapy: a review of tricyclic antidepressants and selective serotonin reuptake inhibitors. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: Antidepressants in long-term therapy: a review of tricyclic antidepressants and selective serotonin reuptake inhibitors. Information

Substance Name: Fluoxetine

Registry Number: 54910-89-3

Grant and Affiliation Information for Antidepressants in long-term therapy: a review of tricyclic antidepressants and selective serotonin reuptake inhibitors.

AFFILIATION: Department of Psychiatry and Behavioral Sciences, The University of Texas Medical Branch, Galveston, USA.

Country: DENMARK

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MEDLINETA: Acta Psychiatr Scand Suppl

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