Antidepressant drugs reverse the loss of adult neural stem cells following chronic stress.

Antidepressant drugs reverse the loss of adult neural stem cells following chronic stress. Research Abstract Details 

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Antidepressant drugs reverse the loss of adult neural stem cells following chronic stress. Abstract Text:

Seiji Hitoshi,Noriko Maruta,Mikito Higashi,Akhilesh Kumar,Nobumasa Kato,Kazuhiro Ikenaka,Seiji Hitoshi,Noriko Maruta,Mikito Higashi,Akhilesh Kumar,Nobumasa Kato,Kazuhiro Ikenaka,Seiji Hitoshi,Noriko Maruta,Mikito Higashi,Akhilesh Kumar,Nobumasa Kato,Kazuhiro Ikenaka,

In rodents, adult neurogenesis occurs in the olfactory bulb and the dentate gyrus of the hippocampus. It has been shown that exposure to psychosocial stress reduces cell proliferation in the dentate gyrus. However, little is known about how stress affects the proliferation kinetics of neural stem cells (NSCs) in the subventricular zone (SVZ), which provide new neurons to the olfactory bulb. We utilized a forced-swim model of stress in the mouse and found that chronic stress decreased the number of NSCs in the SVZ. The reduction of NSC number persisted for weeks after the cessation of stress but was reversed by treatment with the antidepressant drugs fluoxetine and imipramine. We demonstrated by in vitro colony-forming neurosphere assay that corticosterone attenuated neurosphere formation by adult NSCs and, in contrast, that serotonin increased the survival of NSCs. In addition, serotonin expanded the size of the NSC pool in the SVZ when it was infused into the lateral ventricle in vivo. These results suggest that, under chronic stress conditions, the number of NSCs is regulated by the actions of glucocorticoids and serotonin. These data provide insights into the molecular mechanisms underlying the pharmacological actions of antidepressant drugs.

Antidepressant drugs reverse the loss of adult neural stem cells following chronic stress. Publishing Authors By Initials

S Hitoshi,N Maruta,M Higashi,A Kumar,N Kato,K Ikenaka,S Hitoshi,N Maruta,M Higashi,A Kumar,N Kato,K Ikenaka,S Hitoshi,N Maruta,M Higashi,A Kumar,N Kato,K Ikenaka,

For similar nervous system: central nervous system: brain: prosencephalon: telencephalon research abstracts see: nervous system: central nervous system: brain: prosencephalon: telencephalon research

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Antidepressant drugs reverse the loss of adult neural stem cells following chronic stress. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of neuroscience research

VOLUME: 85

Page Numbers: 3574-85

Journal Abbreviation: J. Neurosci. Res.

ISSN: 0360-4012

DAY: 19

MONTH: Dec

YEAR: 2007

Antidepressant drugs reverse the loss of adult neural stem cells following chronic stress. Information

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LANGUAGE: eng

NlmUniqueID: 7600111

Antidepressant drugs reverse the loss of adult neural stem cells following chronic stress. Keywords Mesh Terms:

KEYWORDS: Telencephalon

MESH TERMS: physiopathology

Chemical & Substance for Abstract: Antidepressant drugs reverse the loss of adult neural stem cells following chronic stress. Information

Substance Name: Fluoxetine

Registry Number: 54910-89-3

Grant and Affiliation Information for Antidepressant drugs reverse the loss of adult neural stem cells following chronic stress.

AFFILIATION: Division of Neurobiology and Bioinformatics, National Institute for Physiological Sciences, 5-1 Higashiyama, Myodaiji, Okazaki, Japan. shitoshi@nips.ac.jp

Country: United States

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MEDLINETA: J Neurosci Res

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