Anticoagulant heparan sulfate: structural specificity and biosynthesis.

Anticoagulant heparan sulfate: structural specificity and biosynthesis. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Anticoagulant heparan sulfate: structural specificity and biosynthesis. Abstract Text:

Jian Liu,Lars C Pedersen,

Heparan sulfate (HS) is present on the surface of endothelial and surrounding tissues in large quantities. It plays important roles in regulating numerous functions of the blood vessel wall, including blood coagulation, inflammation response, and cell differentiation. HS is a highly sulfated polysaccharide containing glucosamine and glucuronic/iduronic acid repeating disaccharide units. The unique sulfated saccharide sequences of HS determine its specific functions. Heparin, an analog of HS, is the most commonly used anticoagulant drug. Because of its wide range of biological functions, HS has become an interesting molecule to biochemists, medicinal chemists, and developmental biologists. In this review, we summarize recent progress toward understanding the interaction between HS and blood-coagulating factors, the biosynthesis of anticoagulant HS and the mechanism of action of HS biosynthetic enzymes. Furthermore, knowledge of the biosynthesis of HS facilitates the development of novel enzymatic approaches to synthesize HS from bacterial capsular polysaccharides and to produce polysaccharide end products with high specificity for the biological target. These advancements provide the foundation for the development of polysaccharide-based therapeutic agents.

Anticoagulant heparan sulfate: structural specificity and biosynthesis. Publishing Authors By Initials

J Liu,LC Pedersen,

For similar enzymes and coenzymes: enzymes: transferases: sulfur group transferases: sulfotransferases research abstracts see: enzymes and coenzymes: enzymes: transferases: sulfur group transferases: sulfotransferases research

PUBMED ID PMID:

MEDLINE DATE:

Anticoagulant heparan sulfate: structural specificity and biosynthesis. Journal Published:

PUBLICATION TYPE: Review

Journal: Applied microbiology and biotechnology

VOLUME: 74

Page Numbers: 263-72

Journal Abbreviation: Appl. Microbiol. Biotechnol.

ISSN: 0175-7598

DAY: 28

MONTH: 11

YEAR: 2006

Anticoagulant heparan sulfate: structural specificity and biosynthesis. Information

Number of References: 60

LANGUAGE: eng

NlmUniqueID: 8406612

Anticoagulant heparan sulfate: structural specificity and biosynthesis. Keywords Mesh Terms:

KEYWORDS: Sulfotransferases

MESH TERMS: metabolism

Chemical & Substance for Abstract: Anticoagulant heparan sulfate: structural specificity and biosynthesis. Information

Substance Name: Sulfotransferases

Registry Number: EC 2.8.2.-

Grant and Affiliation Information for Anticoagulant heparan sulfate: structural specificity and biosynthesis.

AFFILIATION: Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina, Rm 309, Beard Hall, Chapel Hill, NC 27599, USA. jian_liu@unc.edu

Country: Germany

AGENCY: United States NIAID

GRANT: AI050050

ACRONYM: AI

MEDLINETA: Appl Microbiol Biotechnol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Anticoagulant heparan sulfate: structural specificity and biosynthesis Related Publications

• A High Throughput In Vivo Model for Testing Delivery and Antiviral Effects of siRNAs in Vertebrates.
• A prospective study of health, life-style and psychosocial predictors of self-rated health.
• Aetiology and prediction of pneumonia in lower respiratory tract infection in primary care.
• Anticoagulant heparan sulfate: structural specificity and biosynthesis.
• Assay of tolfenamic acid and its metabolites by liquid chromatography on dynamically modified silica: Application in pharmacokinetics.
• Biological aspects of social bonding and the roots of human violence.
• Book review: Dynamic Cells: Dynamic Cell Biology of the 21st Century.
• Clinical indices of familial depression in the Swedish Twin Registry.
• Defining the lower limit of normal for FEV1/ FVC.
• EB1 is required for primary cilia assembly in fibroblasts.
• Endorectal magnetic resonance imaging staging of prostate cancer.
• Gender differences in depressive symptoms among older adults: a cross-national comparison: the CLESA project.
• Genotype-environment interactions: cognitive aging and social factors.
• Kinetic modeling and fitting software for interconnected reaction schemes: VisKin.
• Peripherally administered non-peptide oxytocin antagonist, L368,899, accumulates in limbic brain areas: a new pharmacological tool for the study of social motivation in non-human primates.
• Procalcitonin versus C-reactive protein for predicting pneumonia in adults with lower respiratory tract infection in primary care.
• Quantum chemical study of the mechanism of action of vitamin K carboxylase (VKC). IV. Intermediates and transition states.
• Reasons for drinking in the college student context: the differential role and risk of the social motivator.
• Repeated long separations from pups produce depression-like behavior in rat mothers.
• Sensors and signal transduction pathways in vertebrate cell volume regulation.
• Sources of circulating 3,5,3'-triiodothyronine in hyperthyroidism estimated after blocking of type 1 and type 2 iodothyronine deiodinases.
• Structure of the Escherichia coli DNA polymerase III epsilon-HOT proofreading complex.
• Synthesis of twisted intercalating nucleic acids possessing acridine derivatives. Thermal stability studies.
• The cancer cell's "power plants" as promising therapeutic targets: an overview.
• The nuclease a-inhibitor complex is characterized by a novel metal ion bridge.
• The role of IL-6 in mediating the anti-inflammatory effects of exercise.
• Twin pair resemblance for psychiatric hospitalization in the Swedish Twin Registry: a 32-year follow-up study of 29,602 twin pairs.
• Using empirical research to formulate normative ethical principles in biomedicine.
• What causes the enhancement of activity of factor VIIa by tissue factor?
• [Flavonoids in the Flowers of Primula officinalis.]