Antibody responses to vaccinia membrane proteins after smallpox vaccination.

Antibody responses to vaccinia membrane proteins after smallpox vaccination. Research Abstract Details 

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Antibody responses to vaccinia membrane proteins after smallpox vaccination. Abstract Text:

Steven J Lawrence,Kathleen R Lottenbach,Frances K Newman,R Mark L Buller,Clifford J Bellone,John J Chen,Gary H Cohen,Roselyn J Eisenberg,Robert B Belshe,Samuel L Stanley,Sharon E Frey,

BACKGROUND: Vaccinia virus (VV) membrane proteins are candidates for orthopoxvirus subunit vaccines and potential targets for therapeutic antibodies. Human antibody responses to these proteins after VV vaccination have not been well characterized. METHODS: Pre- and postvaccination (day 26-30) serum specimens from 80 VV vaccine recipients were examined for immunoglobulin G antibodies specific for B5, A33, A27, and L1 by enzyme-linked immunosorbent assay (ELISA). Responses were compared between vaccinia-naive and previously vaccinated (nonnaive) recipients and between nonnaive recipients of undiluted or 1 : 10 diluted vaccine. RESULTS: VV vaccination elicited anti-A33 and anti-A27 antibodies in nearly all vaccinia-naive subjects (100% and 93%, respectively). Preexisting antibodies were commonly detected in nonnaive subjects (for anti-B5, 68%; for anti-A33, 59%; for anti-A27, 38%; and for anti-L1, 10%). Anti-B5 antibodies were strongly boosted by undiluted vaccine (geometric mean titer [GMT], 151 vs. 1010 for pre- vs. postvaccination; P<.001), whereas anti-L1 antibody responses were less robust (detection rate, 31%; GMT, 75) in nonnaive subjects. Diluted vaccine elicited antibody responses that were similar to those elicited by undiluted vaccine. CONCLUSIONS: Vaccination with VV elicits long-lived specific antibody responses directed against VV membrane proteins that vary by previous vaccination status but not with respect to 10-fold dilution of vaccine. B5, A33, and A27 should be considered for inclusion in future human orthopoxvirus subunit vaccines.

Antibody responses to vaccinia membrane proteins after smallpox vaccination. Publishing Authors By Initials

SJ Lawrence,KR Lottenbach,FK Newman,RM Buller,CJ Bellone,JJ Chen,GH Cohen,RJ Eisenberg,RB Belshe,SL Stanley,SE Frey,

For similar proteins: viral proteins: viral structural proteins: viral envelope proteins research abstracts see: proteins: viral proteins: viral structural proteins: viral envelope proteins research

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Antibody responses to vaccinia membrane proteins after smallpox vaccination. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of infectious diseases

VOLUME: 196

Page Numbers: 220-9

Journal Abbreviation: J. Infect. Dis.

ISSN: 0022-1899

DAY: 4

MONTH: 06

YEAR: 2007

Antibody responses to vaccinia membrane proteins after smallpox vaccination. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 413675

Antibody responses to vaccinia membrane proteins after smallpox vaccination. Keywords Mesh Terms:

KEYWORDS: Viral Envelope Proteins

MESH TERMS: immunology

Chemical & Substance for Abstract: Antibody responses to vaccinia membrane proteins after smallpox vaccination. Information

Substance Name: Viral Envelope Proteins

Registry Number: 0

Grant and Affiliation Information for Antibody responses to vaccinia membrane proteins after smallpox vaccination.

AFFILIATION: Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO 63110, USA. slawrenc@im.wustl.edu

Country: United States

AGENCY: United States NIAID

GRANT: U54 AI57168

ACRONYM: AI

MEDLINETA: J Infect Dis

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