Antibody recognition of cell surface-associated NS1 triggers Fc-gamma receptor-mediated phagocytosis and clearance of West Nile Virus-infected cells.

Antibody recognition of cell surface-associated NS1 triggers Fc-gamma receptor-mediated phagocytosis and clearance of West Nile Virus-infected cells. Research Abstract Details 

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Antibody recognition of cell surface-associated NS1 triggers Fc-gamma receptor-mediated phagocytosis and clearance of West Nile Virus-infected cells. Abstract Text:

Kyung Min Chung,Bruce S Thompson,Daved H Fremont,Michael S Diamond,

Previous studies have suggested that monoclonal antibodies (MAbs) to flavivirus nonstructural protein-1 (NS-1) protect against infection in mice through an Fc-gamma receptor-dependent pathway. To identify a specific mechanism, we evaluated the protective activity of anti-NS1 MAbs to WNV using mice and cells with deficiencies of specific Fc-gamma receptors. Our results suggest that only MAbs that recognize cell surface-associated NS1 trigger Fc-gamma receptor I- and/or IV-mediated phagocytosis and clearance of WNV-infected cells. These findings may be relevant for generating novel therapeutic MAbs or vaccines against flaviviruses that target the NS1 protein.

Antibody recognition of cell surface-associated NS1 triggers Fc-gamma receptor-mediated phagocytosis and clearance of West Nile Virus-infected cells. Publishing Authors By Initials

KM Chung,BS Thompson,DH Fremont,MS Diamond,

For similar viruses: rna viruses: flaviviridae: flavivirus: encephalitis viruses, japanese: west nile virus research abstracts see: viruses: rna viruses: flaviviridae: flavivirus: encephalitis viruses, japanese: west nile virus research

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Antibody recognition of cell surface-associated NS1 triggers Fc-gamma receptor-mediated phagocytosis and clearance of West Nile Virus-infected cells. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of virology

VOLUME: 81

Page Numbers: 9551-5

Journal Abbreviation: J. Virol.

ISSN: 0022-538X

DAY: 20

MONTH: 06

YEAR: 2007

Antibody recognition of cell surface-associated NS1 triggers Fc-gamma receptor-mediated phagocytosis and clearance of West Nile Virus-infected cells. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 113724

Antibody recognition of cell surface-associated NS1 triggers Fc-gamma receptor-mediated phagocytosis and clearance of West Nile Virus-infected cells. Keywords Mesh Terms:

KEYWORDS: West Nile virus

MESH TERMS: immunology

Chemical & Substance for Abstract: Antibody recognition of cell surface-associated NS1 triggers Fc-gamma receptor-mediated phagocytosis and clearance of West Nile Virus-infected cells. Information

Substance Name: Viral Nonstructural Proteins

Registry Number: 0

Grant and Affiliation Information for Antibody recognition of cell surface-associated NS1 triggers Fc-gamma receptor-mediated phagocytosis and clearance of West Nile Virus-infected cells.

AFFILIATION: Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

Country: United States

AGENCY: United States NIAID

GRANT: U54 AI057160

ACRONYM: AI

MEDLINETA: J Virol

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