Antibody interference with N-acyl homoserine lactone-mediated bacterial quorum sensing.

Antibody interference with N-acyl homoserine lactone-mediated bacterial quorum sensing. Research Abstract Details 

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Antibody interference with N-acyl homoserine lactone-mediated bacterial quorum sensing. Abstract Text:

Gunnar F Kaufmann,Rafaella Sartorio,Sang-Hyeup Lee,Jenny M Mee,Laurence J Altobell,David P Kujawa,Emily Jeffries,Bruce Clapham,Michael M Meijler,Kim D Janda,

Many bacterial pathogens coordinate their virulence factor expression in a cell density-dependent manner. This population-dependent coordination of gene expression in bacteria has been termed "quorum sensing" (QS). N-Acyl homoserine lactones (AHLs) are used by over 70 Gram-negative bacterial species as autoinducers. Inhibition of QS signaling might represent a new target for antimicrobial therapy. Here we report the hapten design, synthesis, generation of monoclonal antibodies (mAbs) against AHLs, and the evaluation of these mAbs for their ability to blunt QS signaling and inhibit virulence factor expression in P. aeruginosa. The mAbs can be envisioned as a tool for future investigations into AHL-based QS, which may aid in gaining new insights into the pathogenesis of P. aeruginosa and may ultimately lead to the development of new strategies to combat bacterial diseases.

Antibody interference with N-acyl homoserine lactone-mediated bacterial quorum sensing. Publishing Authors By Initials

GF Kaufmann,R Sartorio,SH Lee,JM Mee,LJ Altobell,DP Kujawa,E Jeffries,B Clapham,MM Meijler,KD Janda,

For similar bacteria: gram-negative bacteria: gram-negative aerobic bacteria: gram-negative aerobic rods and cocci: pseudomonadaceae: pseudomonas: pseudomonas aeruginosa research abstracts see: bacteria: gram-negative bacteria: gram-negative aerobic bacteria: gram-negative aerobic rods and cocci: pseudomonadaceae: pseudomonas: pseudomonas aeruginosa research

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Antibody interference with N-acyl homoserine lactone-mediated bacterial quorum sensing. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of the American Chemical Society

VOLUME: 128

Page Numbers: 2802-3

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 8

MONTH: Mar

YEAR: 2006

Antibody interference with N-acyl homoserine lactone-mediated bacterial quorum sensing. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7503056

Antibody interference with N-acyl homoserine lactone-mediated bacterial quorum sensing. Keywords Mesh Terms:

KEYWORDS: Pseudomonas aeruginosa

MESH TERMS: immunology

Chemical & Substance for Abstract: Antibody interference with N-acyl homoserine lactone-mediated bacterial quorum sensing. Information

Substance Name: 4-Butyrolactone

Registry Number: 96-48-0

Grant and Affiliation Information for Antibody interference with N-acyl homoserine lactone-mediated bacterial quorum sensing.

AFFILIATION: The Skaggs Institute for Chemical Biology and Departments of Chemistry and Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

Country: United States

AGENCY: United States NIAID

GRANT: AI 055781

ACRONYM: AI

MEDLINETA: J Am Chem Soc

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