Antibody-independent, CD4+ T-cell-dependent protection against pneumococcal colonization elicited by intranasal immunization with purified pneumococcal proteins.

Antibody-independent, CD4+ T-cell-dependent protection against pneumococcal colonization elicited by intranasal immunization with purified pneumococcal proteins. Research Abstract Details 

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Antibody-independent, CD4+ T-cell-dependent protection against pneumococcal colonization elicited by intranasal immunization with purified pneumococcal proteins. Abstract Text:

Alan Basset,Claudette M Thompson,Susan K Hollingshead,David E Briles,Edwin W Ades,Marc Lipsitch,Richard Malley,

Immunity to pneumococcal colonization in mice by exposure to live or killed pneumococci has been shown to be antibody independent but dependent on CD4+ T cells. Here we show that intranasal immunization with pneumococcal proteins (pneumococcal surface protein C, adhesin A, and a pneumolysoid) can elicit a similar mechanism of protection. Colonization could be significantly reduced in mice congenitally deficient in immunoglobulins after intranasal immunization with this mixture of proteins; conversely, the depletion of CD4+ T cells in immunized wild-type mice at the time of challenge eliminated the protection afforded by immunization. Overall, our results show that intranasal immunization with a mixture of pneumococcal proteins protects against colonization in an antibody-independent, CD4+ T-cell-dependent manner.

Antibody-independent, CD4+ T-cell-dependent protection against pneumococcal colonization elicited by intranasal immunization with purified pneumococcal proteins. Publishing Authors By Initials

A Basset,CM Thompson,SK Hollingshead,DE Briles,EW Ades,M Lipsitch,R Malley,

For similar respiratory system: trachea research abstracts see: respiratory system: trachea research

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Antibody-independent, CD4+ T-cell-dependent protection against pneumococcal colonization elicited by intranasal immunization with purified pneumococcal proteins. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Infection and immunity

VOLUME: 75

Page Numbers: 5460-4

Journal Abbreviation: Infect. Immun.

ISSN: 0019-9567

DAY: 13

MONTH: 08

YEAR: 2007

Antibody-independent, CD4+ T-cell-dependent protection against pneumococcal colonization elicited by intranasal immunization with purified pneumococcal proteins. Information

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LANGUAGE: eng

NlmUniqueID: 246127

Antibody-independent, CD4+ T-cell-dependent protection against pneumococcal colonization elicited by intranasal immunization with purified pneumococcal proteins. Keywords Mesh Terms:

KEYWORDS: Trachea

MESH TERMS: microbiology

Chemical & Substance for Abstract: Antibody-independent, CD4+ T-cell-dependent protection against pneumococcal colonization elicited by intranasal immunization with purified pneumococcal proteins. Information

Substance Name: Pneumococcal Vaccines

Registry Number: 0

Grant and Affiliation Information for Antibody-independent, CD4+ T-cell-dependent protection against pneumococcal colonization elicited by intranasal immunization with purified pneumococcal proteins.

AFFILIATION: Division of Infectious Diseases, Children's Hospital Boston, Enders 861.3, 300 Longwood Avenue, Boston, MA 02115, USA.

Country: United States

AGENCY: United States NIAID

GRANT: AI067737

ACRONYM: AI

MEDLINETA: Infect Immun

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