Antibodies to lipoteichoic acid from Staphylococcus aureus. Specificity of murine monoclonal and human antibodies.

Antibodies to lipoteichoic acid from Staphylococcus aureus. Specificity of murine monoclonal and human antibodies. Research Abstract Details 

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Antibodies to lipoteichoic acid from Staphylococcus aureus. Specificity of murine monoclonal and human antibodies. Abstract Text:

Two monoclonal antibodies against staphylococcal lipoteichoic acid (LTA) were made by fusing P3X63Ag8 myeloma cells and splenocytes from mice immunized with purified LTA. Both were isotyped as being IgM kappa. Their specificities were determined by enzyme-linked immunosorbent assays indicating that both antibodies reacted with the glycerol-phosphate backbone, while one of them also had some affinity for the alanyl substituent. Antibodies in serum from 7 multiple sclerosis (MS) patients and serum and cerebrospinal fluid (CSF) from 7 non-MS patients apparently reacted with the sugar moiety of LTA. In contrast, CSF antibodies from 6 of the 7 MS patients and 1 of the 7 non-MS patients had affinity for the alanine residue. This non-MS patient also had serum antibodies against the alanine residue. None of the other sera tested appeared to contain such antibodies.

Antibodies to lipoteichoic acid from Staphylococcus aureus. Specificity of murine monoclonal and human antibodies. Publishing Authors By Initials

For similar carbohydrates: glycosides: teichoic acids research abstracts see: carbohydrates: glycosides: teichoic acids research

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MEDLINE DATE:

Antibodies to lipoteichoic acid from Staphylococcus aureus. Specificity of murine monoclonal and human antibodies. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Acta pathologica, microbiologica, et immunologica

VOLUME: 93

Page Numbers: 245-50

Journal Abbreviation:

ISSN: 0108-0202

DAY: 26

MONTH: Dec

YEAR: 1985

Antibodies to lipoteichoic acid from Staphylococcus aureus. Specificity of murine monoclonal and human antibodies. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8206624

Antibodies to lipoteichoic acid from Staphylococcus aureus. Specificity of murine monoclonal and human antibodies. Keywords Mesh Terms:

KEYWORDS: Teichoic Acids

MESH TERMS: immunology

Chemical & Substance for Abstract: Antibodies to lipoteichoic acid from Staphylococcus aureus. Specificity of murine monoclonal and human antibodies. Information

Substance Name: lipoteichoic acid

Registry Number: 56411-57-5

Grant and Affiliation Information for Antibodies to lipoteichoic acid from Staphylococcus aureus. Specificity of murine monoclonal and human antibodies.

AFFILIATION:

Country: DENMARK

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MEDLINETA: Acta Pathol Microbiol Immunol

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