[Antibiotic therapy in leukopenia]

[Antibiotic therapy in leukopenia] Research Abstract Details 

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[Antibiotic therapy in leukopenia] Abstract Text:

Intensified chemotherapy-induced long-term neutropenia is the main cause for morbidity and mortality of patients with hematologic malignancies. The successful management of neutropenia is based on hygienic procedures antimicrobial prophylaxis and therapy, and diagnostics. Until today, Co-Trimoxazole or fluoroquinolenes and oral amphotericine B are the prophylactic standard. The initial therapy of febrile neutropenia has to be started empirically before identification of causative pathogens or infectious foci. The febrile episodes should be treated with broad spectrum antibiotics (combinations or monotherapy) due to the spectrum of microorganisms or resistance situation at hospital. In case of non-response after 3-4 days the initial therapy should be modified, in addition to further antibacterial therapy the start with an antifungal drug has to be recommended. In patients with pulmonary infiltrates the early treatment with amphotericine B has been shown to be more advantageous than delayed antifungal therapy. Furthermore, the antibiotic therapy is based on proven microorganisms, susceptibility testing and infectious foci. The value of interventional treatment with G-CSF or GM-CSF is controversely discussed. An uncompromising handling of febrile neutropenia is necessary to reduce the mortality due to infections in patients with hematologic malignancies.

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[Antibiotic therapy in leukopenia] Journal Published:

PUBLICATION TYPE: Review

Journal: Praxis

VOLUME: 87

Page Numbers: 1120-5

Journal Abbreviation:

ISSN: 1661-8157

DAY: 2

MONTH: Sep

YEAR: 1998

[Antibiotic therapy in leukopenia] Information

Number of References: 43

LANGUAGE: ger

NlmUniqueID: 101468093

[Antibiotic therapy in leukopenia] Keywords Mesh Terms:

KEYWORDS: Risk Factors

MESH TERMS: drug therapy

Chemical & Substance for Abstract: [Antibiotic therapy in leukopenia] Information

Substance Name: Antineoplastic Agents

Registry Number: 0

Grant and Affiliation Information for [Antibiotic therapy in leukopenia]

AFFILIATION: Med. Klinik III, J.-W.-Goethe-Universität, Frankfurt/M.

Country: SWITZERLAND

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MEDLINETA: Praxis (Bern 1994)

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