Two new monoterpenoids, 8,10-dihydroxy-9(2)-methylbutyryloxythymol (1) and 10-hydroxy-8,9-dioxyisopropylidene-thymol (2), together with five known thymol derivatives: 8,9,10-trihydroxythymol (3), thymol-beta-glucopyranoside (4), 9-hydroxythymol (5), 8,10-dihydroxy-9-isobutyryloxythymol (6), and 8-hydroxy-9,10-diisobutyryloxythymol (7), were isolated from Centipeda minima. Their structures were identified by means of spectroscopic analyses. Interestingly, compound 2 is not an extraction artifact according to a close HPLC examination of material after extraction by analytical MeOH at ambient temperature. The antibacterial activities of compounds 1-7 were evaluated against eight microbial strains by the agar dilution method.
Antibacterial thymol derivatives isolated from Centipeda minima. Publishing Authors By Initials
Antibacterial thymol derivatives isolated from Centipeda minima. Journal Published:
PUBLICATION TYPE: Research Support, Non-U.S. Gov
Journal: Molecules (Basel, Switzerland)
VOLUME: 12
Page Numbers: 1606-13
Journal Abbreviation:
ISSN: 1420-3049
DAY: 27
MONTH: 01
YEAR: 2007
Antibacterial thymol derivatives isolated from Centipeda minima. Information
Number of References:
LANGUAGE: eng
NlmUniqueID: 100964009
Antibacterial thymol derivatives isolated from Centipeda minima. Keywords Mesh Terms:
KEYWORDS: Thymol
MESH TERMS: analogs & derivatives
Chemical & Substance for Abstract: Antibacterial thymol derivatives isolated from Centipeda minima. Information
Substance Name: Thymol
Registry Number: 89-83-8
Grant and Affiliation Information for Antibacterial thymol derivatives isolated from Centipeda minima.
AFFILIATION: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China.
Country: Switzerland
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MEDLINETA: Molecules
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