Antibacterial activities of poly(amidoamine) dendrimers terminated with amino and poly(ethylene glycol) groups.

Antibacterial activities of poly(amidoamine) dendrimers terminated with amino and poly(ethylene glycol) groups. Research Abstract Details 

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Antibacterial activities of poly(amidoamine) dendrimers terminated with amino and poly(ethylene glycol) groups. Abstract Text:

Michelle K Calabretta,Amit Kumar,Alison M McDermott,Chengzhi Cai,

Poly(amidoamine) (PAMAM) dendrimer derivatives have been investigated for their biological applications, especially for delivery of drugs, including antimicrobial drugs to eukaryotic cells, but their effects on bacterial cells are largely unexplored. Herein we report that amino-terminated PAMAM dendrimers are highly toxic to the common Gram-negative pathogen Pseudomonas aeruginosa. The concentration that kills 50% of the bacteria (EC50) was in the range of approximately 0.9-1.5 microg/mL for the generation 5, amino-terminated dendrimers with or without partial (43%) coating of poly(ethylene glycol) (PEG). These EC50 values were lower than that ( approximately 1.9-2.8 microg/mL) for LL-37, a potent antimicrobial peptide expressed in a variety of epithelia. On the contrary, the dendrimers were far less toxic (EC50 > 21 microg/mL) to the Gram-positive pathogen Staphylococcus aureus than LL-37 (EC50 = approximately 1.9 microg/mL). In agreement with the previous studies on other cell types, the dendrimers were not cytotoxic to human corneal epithelial cells at the concentrations that were toxic to P. aeruginosa. Our findings indicate that amino-terminated PAMAM dendrimers and their partially PEG-coated derivatives possess attractive antimicrobial properties, particularly against Gram-negative bacteria, thus expanding the potential biological application of the dendrimers.

Antibacterial activities of poly(amidoamine) dendrimers terminated with amino and poly(ethylene glycol) groups. Publishing Authors By Initials

MK Calabretta,A Kumar,AM McDermott,C Cai,

For similar bacteria: gram-positive bacteria: gram-positive cocci: staphylococcaceae: staphylococcus: staphylococcus aureus research abstracts see: bacteria: gram-positive bacteria: gram-positive cocci: staphylococcaceae: staphylococcus: staphylococcus aureus research

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Antibacterial activities of poly(amidoamine) dendrimers terminated with amino and poly(ethylene glycol) groups. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Biomacromolecules

VOLUME: 8

Page Numbers: 1807-11

Journal Abbreviation: Biomacromolecules

ISSN: 1525-7797

DAY: 19

MONTH: 05

YEAR: 2007

Antibacterial activities of poly(amidoamine) dendrimers terminated with amino and poly(ethylene glycol) groups. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100892849

Antibacterial activities of poly(amidoamine) dendrimers terminated with amino and poly(ethylene glycol) groups. Keywords Mesh Terms:

KEYWORDS: Staphylococcus aureus

MESH TERMS: metabolism

Chemical & Substance for Abstract: Antibacterial activities of poly(amidoamine) dendrimers terminated with amino and poly(ethylene glycol) groups. Information

Substance Name: Polyethylene Glycols

Registry Number: 0

Grant and Affiliation Information for Antibacterial activities of poly(amidoamine) dendrimers terminated with amino and poly(ethylene glycol) groups.

AFFILIATION: Department of Chemistry, University of Houston, Houston, Texas 77204, USA.

Country: United States

AGENCY: United States NEI

GRANT: EY13175

ACRONYM: EY

MEDLINETA: Biomacromolecules

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