Antiatherogenic effect of isoflavones in ovariectomized apolipoprotein e-deficient mice.

Antiatherogenic effect of isoflavones in ovariectomized apolipoprotein e-deficient mice. Research Abstract Details 

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Antiatherogenic effect of isoflavones in ovariectomized apolipoprotein e-deficient mice. Abstract Text:

Masao Sato,Hiroyoshi Sato,Akiko Ogawa,Run Nomura,Shinichiro Takashima,Hyun-Jung Bang,Hiromi Matsuoka,Katsumi Imaizumi,Masao Sato,Hiroyoshi Sato,Akiko Ogawa,Run Nomura,Shinichiro Takashima,Hyun-Jung Bang,Hiromi Matsuoka,Katsumi Imaizumi,

The consumption of isoflavone-containing foods such as soybean and soybean products has been reported to have beneficial effects on the cardiovascular system in postmenopausal women. The present study was carried out to examine the mechanism underlying the beneficial effects of isoflavones in apolipoprotein (apo) E-deficient mice subjected to ovarian resection. Compared with sham-operated mice, ovariectomized mice had a larger arterial lesion area in the aortic root. Feeding the ovariectomized mice an isoflavone-containing diet (0.055 mg/kJ of total isoflavones/cal of diet) reduced the size of these lesions more than did feeding them with an isoflavone-free diet. Neither ovariectomy nor diet had a significant effect on the concentration of cholesterol in serum and urinary levels of isoprostanes, which are biomarkers for oxidative stress in vivo. The ovariectomized mice showed a greater increase in mRNA abundance for monocyte chemoattractant protein (MCP)-I in the aorta and in the level of nitric oxide (NO) secreted by peritoneal macrophages in culture than did the sham-operated mice. The isoflavone-containing diet lowered the MCP-I expression and the NO secretion more than did the isoflavone-free diet. These results suggest that dietary isoflavones confer an antiatherogenic effect by preventing the activation of macrophages due to the removal of ovaries.

Antiatherogenic effect of isoflavones in ovariectomized apolipoprotein e-deficient mice. Publishing Authors By Initials

M Sato,H Sato,A Ogawa,R Nomura,S Takashima,HJ Bang,H Matsuoka,K Imaizumi,M Sato,H Sato,A Ogawa,R Nomura,S Takashima,HJ Bang,H Matsuoka,K Imaizumi,

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Antiatherogenic effect of isoflavones in ovariectomized apolipoprotein e-deficient mice. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of agricultural and food chemistry

VOLUME: 55

Page Numbers: 8967-71

Journal Abbreviation: J. Agric. Food Chem.

ISSN: 0021-8561

DAY: 29

MONTH: 09

YEAR: 2007

Antiatherogenic effect of isoflavones in ovariectomized apolipoprotein e-deficient mice. Information

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LANGUAGE: eng

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AFFILIATION: Laboratory of Nutrition Chemistry, Faculty of Agriculture, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, 6-10-1, Hakozaki, Higashi-ku, Fukuoka, Fukuoka 812-8581, Japan.

Country: United States

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MEDLINETA: J Agric Food Chem

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