Antiarrhythmic properties of acetaminophen in the dog.

Antiarrhythmic properties of acetaminophen in the dog. Research Abstract Details 

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Antiarrhythmic properties of acetaminophen in the dog. Abstract Text:

Gary F Merrill,Jared H Merrill,Roseli Golfetti,Kathryn M Jaques,Norell S Hadzimichalis,Sunanda S Baliga,Tyler H Rork,

Mongrel dogs bred for research and weighing 25 +/- 3 kg were used to test the hypothesis that acetaminophen has antiar-rhythmic properties. Only ventricular arrhythmias defined by the Lambeth Conventions were investigated. Dogs were exposed either to 60 mins of regional myocardial ischemia followed by 180 mins of reperfusion (n = 14) or were administered a high dose of ouabain (n = 14). Both groups of 14 dogs were further divided into vehicle and acetaminophen treatment groups (n = 7 in each). During selected 10-min intervals, we recorded the numbers of ventricular premature beats, ventricular salvos, ventricular bigeminy, ventricular tachycardia (nonsustained and sustained), and we recorded the heart rate, systemic arterial blood pressure, and left ventricular function. Neither heart rate nor the number of ventricular arrhythmias differed significantly under baseline conditions. Conversely, the combined average number of ventricular ectopic beats during ischemia and reperfusion was significantly less in the presence of acetaminophen (28 +/- 4 vs. 6 +/- 1; P < 0.05). Similarly, percent ectopy during reperfusion in vehicle- and acetaminophen-treated dogs was 1.4 +/- 0.4 and 0.4 +/- 0.2, respectively (P < 0.05). The number of all ventricular ectopic beats except ventricular salvos was also significantly reduced in the presence of acetaminophen. Similar results were obtained with ouabain. Our results reveal that systemic administration of a therapeutic dose of acetaminophen has previously unreported antiarrhythmic effects in the dog.

Antiarrhythmic properties of acetaminophen in the dog. Publishing Authors By Initials

GF Merrill,JH Merrill,R Golfetti,KM Jaques,NS Hadzimichalis,SS Baliga,TH Rork,

For similar cardiovascular diseases: vascular diseases: reperfusion injury research abstracts see: cardiovascular diseases: vascular diseases: reperfusion injury research

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Antiarrhythmic properties of acetaminophen in the dog. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Experimental biology and medicine (Maywood, N.J.)

VOLUME: 232

Page Numbers: 1245-52

Journal Abbreviation: Exp. Biol. Med. (Maywood)

ISSN: 1535-3702

DAY: 27

MONTH: Oct

YEAR: 2007

Antiarrhythmic properties of acetaminophen in the dog. Information

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LANGUAGE: eng

NlmUniqueID: 100973463

Antiarrhythmic properties of acetaminophen in the dog. Keywords Mesh Terms:

KEYWORDS: Reperfusion Injury

MESH TERMS: drug therapy

Chemical & Substance for Abstract: Antiarrhythmic properties of acetaminophen in the dog. Information

Substance Name: Acetaminophen

Registry Number: 103-90-2

Grant and Affiliation Information for Antiarrhythmic properties of acetaminophen in the dog.

AFFILIATION: Division of Life Sciences, Department of Cell Biology and Neurosciences, Rutgers University, Piscataway, New Jersey 08854, USA. Merrill@biology.rutgers.edu

Country: United States

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MEDLINETA: Exp Biol Med (Maywood)

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