Antiapoptotic effect of implanted embryonic stem cell-derived early-differentiated cells in aging rats after myocardial infarction.

Antiapoptotic effect of implanted embryonic stem cell-derived early-differentiated cells in aging rats after myocardial infarction. Research Abstract Details 

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Antiapoptotic effect of implanted embryonic stem cell-derived early-differentiated cells in aging rats after myocardial infarction. Abstract Text:

Meixiang Xiang,Jianan Wang,Emel Kaplan,Peter Oettgen,Lewis Lipsitz,James P Morgan,Jiang-Yong Min,Meixiang Xiang,Jianan Wang,Emel Kaplan,Peter Oettgen,Lewis Lipsitz,James P Morgan,Jiang-Yong Min,

This study tested whether implanted embryonic stem cell-derived early-differentiated cells (EDCs) lead to improvement in cardiac function by preventing cardiac apoptosis in aging rats after myocardial infarction. Cardiac apoptosis after transplantation of EDCs was assessed in situ by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end-labeling reaction (TUNEL) staining as well as by measurements of protein levels of cleaved caspases 3, Bax, and Bcl-2. Our results indicate that cell transplantation improved cardiac function at 6-months observation. The frequency of apoptotic cells in the peri-infarcted myocardium 3 days after cell transplantation was significantly decreased in the cell transplantation group. EDC therapy decreased the protein levels of cleaved caspase 3 and Bax, and increased the level of Bcl-2 in comparison to myocardial infarction control. Additionally, the number of apoptotic cells decreased significantly in cardiomyocytes precocultured with EDCs. This study demonstrates that functional improvement of EDC transplantation may at least in part be related to a reduction in cardiomyocyte apoptosis.

Antiapoptotic effect of implanted embryonic stem cell-derived early-differentiated cells in aging rats after myocardial infarction. Publishing Authors By Initials

M Xiang,J Wang,E Kaplan,P Oettgen,L Lipsitz,JP Morgan,JY Min,M Xiang,J Wang,E Kaplan,P Oettgen,L Lipsitz,JP Morgan,JY Min,

For similar animals: animal population groups: animals, inbred strains: rats, inbred strains: rats, inbred f344 research abstracts see: animals: animal population groups: animals, inbred strains: rats, inbred strains: rats, inbred f344 research

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Antiapoptotic effect of implanted embryonic stem cell-derived early-differentiated cells in aging rats after myocardial infarction. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The journals of gerontology. Series A, Biological

VOLUME: 61

Page Numbers: 1219-27

Journal Abbreviation: J. Gerontol. A Biol. Sci. Med.

ISSN: 1079-5006

DAY: 3

MONTH: Dec

YEAR: 2006

Antiapoptotic effect of implanted embryonic stem cell-derived early-differentiated cells in aging rats after myocardial infarction. Information

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LANGUAGE: eng

NlmUniqueID: 9502837

Antiapoptotic effect of implanted embryonic stem cell-derived early-differentiated cells in aging rats after myocardial infarction. Keywords Mesh Terms:

KEYWORDS: Rats, Inbred F344

MESH TERMS: therapy

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Grant and Affiliation Information for Antiapoptotic effect of implanted embryonic stem cell-derived early-differentiated cells in aging rats after myocardial infarction.

AFFILIATION: The 2nd Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, China.

Country: United States

AGENCY: United States NIA

GRANT: 5P60 AG08812-13

ACRONYM: AG

MEDLINETA: J Gerontol A Biol Sci Med Sci

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