Antiangiogenesis treatment for glioblastoma multiforme: challenges and opportunities.

Antiangiogenesis treatment for glioblastoma multiforme: challenges and opportunities. Research Abstract Details 

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Antiangiogenesis treatment for glioblastoma multiforme: challenges and opportunities. Abstract Text:

Angiogenesis is a major hallmark of cancer cells, and glioblastomas are among the most angiogenic tumors. The cascade of angiogenesis is probably initiated by hypoxia, leading to the production of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF). Both VEGF and bFGF have paracrine effects on endothelial cells, pericytes, or both, causing the formation of hyperpermeable tumor blood vessels. Advanced MRI techniques, such as dynamic contrast-enhanced, dynamic susceptibility, and arterial spin labeling MRI, have provided semiquantitative measurements of tumor vascular permeability and perfusion. A decrease in vascular permeability and perfusion can be detected after antiangiogenesis drug treatment, either with monoclonal antibody such as bevacizumab that sequesters VEGF, or small-molecule VEGF receptor tyrosine kinase inhibitors. Therefore, antiangiogenesis therapies are being increasingly adopted for treating glioblastomas. However, caution must be exercised because neural stem cells are also sensitive to antiangiogenesis drugs and the combined effect of ionizing radiation. This article summarizes 30 years of laboratory and clinical research on glioblastoma angiogenesis and discusses its underlying biology, clinical trial results, vascular neuroimaging, and the potential side effects of antiangiogenesis treatment.

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Antiangiogenesis treatment for glioblastoma multiforme: challenges and opportunities. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of the National Comprehensive Cancer Netwo

VOLUME: 6

Page Numbers: 515-22

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ISSN: 1540-1405

DAY: 21

MONTH: May

YEAR: 2008

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LANGUAGE: eng

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Grant and Affiliation Information for Antiangiogenesis treatment for glioblastoma multiforme: challenges and opportunities.

AFFILIATION: Brain Tumor Center & Neuro-Oncology Unit, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA. ewong@bidmc.harvard.edu

Country: United States

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MEDLINETA: J Natl Compr Canc Netw

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