Anti-tumor metastatic activity of beta-glucan purified from mutated Saccharomyces cerevisiae.

Anti-tumor metastatic activity of beta-glucan purified from mutated Saccharomyces cerevisiae. Research Abstract Details 

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Anti-tumor metastatic activity of beta-glucan purified from mutated Saccharomyces cerevisiae. Abstract Text:

Taek Joon Yoon,Tack Joong Kim,Hwa Lee,Kwang Soon Shin,Yeo Pyo Yun,Won Kook Moon,Dong Woo Kim,Kwang Ho Lee,Taek Joon Yoon,Tack Joong Kim,Hwa Lee,Kwang Soon Shin,Yeo Pyo Yun,Won Kook Moon,Dong Woo Kim,Kwang Ho Lee,Taek Joon Yoon,Tack Joong Kim,Hwa Lee,Kwang Soon Shin,Yeo Pyo Yun,Won Kook Moon,Dong Woo Kim,Kwang Ho Lee,Taek Joon Yoon,Tack Joong Kim,Hwa Lee,Kwang Soon Shin,Yeo Pyo Yun,Won Kook Moon,Dong Woo Kim,Kwang Ho Lee,

The beta-glucans isolated from Saccharomyces cerevisiae (S. cerevisiae) enhance the innate immune system, but there is little evidence for its antitumor activity. To examine the antitumor and immunostimulating activities of beta-glucan (IS-2) purified from mutated S. cerevisiae, we made an experiment on innate immune response against metastasis of cancer cells by comparing with the beta-glucan from wild-type S. cerevisiae. In experimental lung metastasis of colon 26-M3.1 carcinoma or B16-BL6 melanoma cells, prophylactic administration of beta-glucan purified from mutated S. cerevisiae significantly inhibited lung metastasis in a dose-dependent manner. Furthermore, therapeutic administration of IS-2 also significantly inhibited the colon 26-M3.1 cell growth in mice. In an assay of liver and spleen metastasis produced by i.v. inoculation of L5178Y-ML25 lymphoma cells, IS-2 also significantly inhibited metastasis in CDF1 mice. Furthermore, pretreatment with IS-2 two days before tumor inoculation significantly prolonged the survival time of tumor-bearing mice. In an in vitro cytotoxicity analysis, IS-2 (up to 100 mug/ml) did not affect the growth of colon 26-M3.1 cells. In contrast, IS-2 enhanced splenocyte proliferating activity in a dose-dependent manner. Peritoneal macrophages stimulated with IS-2 produced various cytokines, such as IL-1beta, IFN-gamma, and IL-12. In addition, treatment with IS-2 (20 mug/mouse) induced tumoricidal activity of peritoneal macrophages against colon 26-M3.1 cells. In an assay for natural killer (NK) cell activity, IS-2 (20 mug/mouse, i.v.) significantly augmented NK cytotoxicity against Yac-1 tumor cells at 2 days after IS-2 treatment. The depletion of NK cells by injection of rabbit anti-asialo GM1 serum abolished the inhibitory effect of IS-2 on lung metastasis of colon 26-M3.1 cells. These data suggest that IS-2 inhibits tumor metastasis via activation of macrophages and NK cells.

Anti-tumor metastatic activity of beta-glucan purified from mutated Saccharomyces cerevisiae. Publishing Authors By Initials

TJ Yoon,TJ Kim,H Lee,KS Shin,YP Yun,WK Moon,DW Kim,KH Lee,TJ Yoon,TJ Kim,H Lee,KS Shin,YP Yun,WK Moon,DW Kim,KH Lee,TJ Yoon,TJ Kim,H Lee,KS Shin,YP Yun,WK Moon,DW Kim,KH Lee,TJ Yoon,TJ Kim,H Lee,KS Shin,YP Yun,WK Moon,DW Kim,KH Lee,

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Anti-tumor metastatic activity of beta-glucan purified from mutated Saccharomyces cerevisiae. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International immunopharmacology

VOLUME: 8

Page Numbers: 36-42

Journal Abbreviation: Int. Immunopharmacol.

ISSN: 1567-5769

DAY: 30

MONTH: 10

YEAR: 2007

Anti-tumor metastatic activity of beta-glucan purified from mutated Saccharomyces cerevisiae. Information

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LANGUAGE: eng

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AFFILIATION: Bio-Food and Drug Research Center and Department of Biotechnology, College of Biomedical and Health Science, Konkuk University, Chungju 380-701, Republic of Korea; Department of Food and Nutrition, Yuhan College, Bucheon 422-749, Republic of Korea.

Country: Netherlands

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MEDLINETA: Int Immunopharmacol

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