Anti-tumor immunostimulatory effect of heat-killed tumor cells.

Anti-tumor immunostimulatory effect of heat-killed tumor cells. Research Abstract Details 

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Anti-tumor immunostimulatory effect of heat-killed tumor cells. Abstract Text:

Taek Joon Yoon,Ji Yeon Kim,Hyojeong Kim,Changwan Hong,Hyunji Lee,Chang Kwon Lee,Kwang Ho Lee,Seokmann Hong,Se Ho Park,

As a part of our ongoing search for a safe and efficient anti-tumor vaccine, we attempted to determine whether the molecular nature of certain tumor antigens would influence immune responses against tumor cells. As compared with freeze-thawed or formaldehyde-fixed tumor antigens, heat-denatured tumor antigens elicited profound anti-tumor immune responses and greatly inhibited the growth of live tumor cells. The heat-denatured tumor antigens induced a substantial increase in the anti-tumor CTL response in the absence of any adjuvant material. This response appears to be initiated by strong activation of the antigen-presenting cells, which may recognize heat-denatured protein antigens. Upon recognition of the heat-denatured tumor antigens, macrophages and dendritic cells were found to acutely upregulate the expression of co-stimulatory molecules such as B7.2, as well as the secretion of inflammatory cytokines such as IL-12 and TNF-alpha. The results of this study indicate that heat-denatured tumor extracts might elicit protective anti-tumor adaptive immune responses and also raise the possibility that a safe and efficient adjuvant-free tumor vaccine might be developed in conjunction with a dendritic cell-based tumor vaccine.

Anti-tumor immunostimulatory effect of heat-killed tumor cells. Publishing Authors By Initials

TJ Yoon,JY Kim,H Kim,C Hong,H Lee,CK Lee,KH Lee,S Hong,SH Park,

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Anti-tumor immunostimulatory effect of heat-killed tumor cells. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Experimental & molecular medicine

VOLUME: 40

Page Numbers: 130-44

Journal Abbreviation: Exp. Mol. Med.

ISSN: 1226-3613

DAY: 29

MONTH: Feb

YEAR: 2008

Anti-tumor immunostimulatory effect of heat-killed tumor cells. Information

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LANGUAGE: eng

NlmUniqueID: 9607880

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Grant and Affiliation Information for Anti-tumor immunostimulatory effect of heat-killed tumor cells.

AFFILIATION: MD Bioalpha Inc., Suwon 443-813, Korea.

Country: Korea (South)

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MEDLINETA: Exp Mol Med

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