Anti-tumor activity of ESX1 on cancer cells harboring oncogenic K-ras mutation.

Anti-tumor activity of ESX1 on cancer cells harboring oncogenic K-ras mutation. Research Abstract Details 

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Anti-tumor activity of ESX1 on cancer cells harboring oncogenic K-ras mutation. Abstract Text:

Human ESX1 is a 65-kilodalton (kDa) paired-like homeoprotein that is proteolytically processed into N-terminal 45-kDa and C-terminal 20-kDa fragments. The N-terminal ESX1 fragment, which contains the homeodomain, localizes to the nucleus and represses mRNA transcription from the K-ras gene. When we inoculated human colorectal carcinoma HCT116 constitutive expressing N-terminal region of ESX1 (N-ESX1) into nude mice, transfectant cells uniformly showed decreased tumor-forming activity compared with that of the parental cells. Furthermore, pretreatment of HCT116 carcinoma cells with a fusion protein consisting of N-ESX1 and the protein-transduction domain derived from the human immunodeficiency virus type-1 TAT protein gave rise to a dramatic reduction in the tumorigenicity of HCT116 cells in nude mice. Our results provide first in vivo evidence for the molecular targeting therapeutic application of the K-ras repressor ESX1, especially TAT-mediated transduction of N-ESX1, in the treatment of human cancers having oncogenic K-ras mutations.

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Anti-tumor activity of ESX1 on cancer cells harboring oncogenic K-ras mutation. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biochemical and biophysical research communication

VOLUME: 370

Page Numbers: 189-94

Journal Abbreviation: Biochem. Biophys. Res. Commun.

ISSN: 1090-2104

DAY: 24

MONTH: 03

YEAR: 2008

Anti-tumor activity of ESX1 on cancer cells harboring oncogenic K-ras mutation. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Anti-tumor activity of ESX1 on cancer cells harboring oncogenic K-ras mutation.

AFFILIATION: Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo 060-0815, Japan.

Country: United States

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MEDLINETA: Biochem Biophys Res Commun

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