[Anti-tumor activity and immune responses induced by human cancer-associated mucin core peptide]

[Anti-tumor activity and immune responses induced by human cancer-associated mucin core peptide] Research Abstract Details 

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[Anti-tumor activity and immune responses induced by human cancer-associated mucin core peptide] Abstract Text:

Y Ma,M Yuan,L Fei,

Mucin molecules are displayed on most human cancer cell surface, and are different from that expressed on normal epithelial cells. The molecular structure of mucin core peptide (apomucin) was identified recently. However, the function of apomucin is only poorly understood. To further elucidate the role of apomucin in the modulation of cancers, this study was to investigate the immune responses induced by mucin core peptide in mice. The mucin core peptide was isolated from pancreatic cancer cell line SW1990. When mice immunized with this apomucin (10 micrograms/time x 6) plus DETOX, all mice developed delayed-type hypersensitivity (DTH) after challanged with apomucin or synthetic mucin core peptide MUC-2 or MUC-3, while the mice immunized with only apomucin did not develop DTH. No antibodies were detected by ELISA after immunization. When the splenic cells of vaccinated mice were cocultured with this apomucin (10-50 micrograms/ml) and rhIL-2 (50 U/ml) in vitro, the proliferated lymphocytes showed cytotoxicity against human cancer cells, including colon cancer, gastric cancer, pancreatic cancer and leukemia as measured by Cr-51 release assay. The cytotoxicity could be blocked by antibodies against MUC-2 and MUC-3. These results provide a rational basis for the use of apomucin as a vaccine to stimulate anti-tumor immunity.

[Anti-tumor activity and immune responses induced by human cancer-associated mucin core peptide] Publishing Authors By Initials

Y Ma,M Yuan,L Fei,

For similar biological factors: biological markers: tumor markers, biological research abstracts see: biological factors: biological markers: tumor markers, biological research

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[Anti-tumor activity and immune responses induced by human cancer-associated mucin core peptide] Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Zhonghua zhong liu za zhi [Chinese journal of onco

VOLUME: 18

Page Numbers: 419-21

Journal Abbreviation: Zhonghua Zhong Liu Za Zhi

ISSN: 0253-3766

DAY: 1

MONTH: Nov

YEAR: 1996

[Anti-tumor activity and immune responses induced by human cancer-associated mucin core peptide] Information

Number of References:

LANGUAGE: chi

NlmUniqueID: 7910681

[Anti-tumor activity and immune responses induced by human cancer-associated mucin core peptide] Keywords Mesh Terms:

KEYWORDS: Tumor Markers, Biological

MESH TERMS: immunology

Chemical & Substance for Abstract: [Anti-tumor activity and immune responses induced by human cancer-associated mucin core peptide] Information

Substance Name: apomucin

Registry Number: 0

Grant and Affiliation Information for [Anti-tumor activity and immune responses induced by human cancer-associated mucin core peptide]

AFFILIATION: General Hospital of PLA, Cancer Research Laboratory, Beijing.

Country: CHINA

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MEDLINETA: Zhonghua Zhong Liu Za Zhi

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