Anti-TGF-beta2 antibody therapy inhibits postoperative resynostosis in craniosynostotic rabbits.

Anti-TGF-beta2 antibody therapy inhibits postoperative resynostosis in craniosynostotic rabbits. Research Abstract Details 

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Anti-TGF-beta2 antibody therapy inhibits postoperative resynostosis in craniosynostotic rabbits. Abstract Text:

Mark P Mooney,H Wolfgang Losken,Amr M Moursi,James Bradley,Kodi Azari,T Oguz Acarturk,Gregory M Cooper,Brian Thompson,Lynne A Opperman,Michael I Siegel,

BACKGROUND: Postoperative resynostosis is a common clinical finding. It has been suggested that an overexpression of transforming growth factor (TGF)-beta2 may be related to craniosynostosis and may contribute to postoperative resynostosis. Interference with TGF-beta2 function with the use of neutralizing antibodies may inhibit resynostosis. The present study was designed to test this hypothesis. METHODS: New Zealand White rabbits with bilateral coronal suture synostosis were used as suturectomy controls (group 1, n = 9) or given suturectomy with nonspecific, control immunoglobulin G antibody (group 2, n = 9) or suturectomy with anti-TGF-beta2 antibody (group 3, n = 11). At 10 days of age, a 3 x 15-mm coronal suturectomy was performed. The sites in groups 2 and 3 were immediately filled with 0.1 cc of a slowly resorbing collagen gel mixed with either immunoglobulin G (100 mug per suture) or anti-TGF-beta2 (100 mug per suture). Three-dimensional computed tomography scan reconstructions of the defects were obtained at 10, 25, 42, and 84 days of age, and the sutures were harvested for histomorphometric analysis. RESULTS: Computed tomography scan data revealed that the suturectomy sites treated with anti-TGF-beta2 showed significantly (p < 0.05) greater areas through 84 days of age compared with controls. Histomorphometry also showed that suturectomy sites treated with anti-TGF-beta2 had patent suturectomy sites and more fibrous tissue in the defects compared with sites in control rabbits and had significantly (p < 0.001) less new bone area (by approximately 215 percent) in the suturectomy site. CONCLUSIONS: These data support the initial hypothesis that interference with TGF-beta2 function inhibited postoperative resynostosis in this rabbit model. They also suggest that this biologically based therapy may be a potential surgical adjunct to retard postoperative resynostosis in infants with craniosynostosis.

Anti-TGF-beta2 antibody therapy inhibits postoperative resynostosis in craniosynostotic rabbits. Publishing Authors By Initials

MP Mooney,HW Losken,AM Moursi,J Bradley,K Azari,TO Acarturk,GM Cooper,B Thompson,LA Opperman,MI Siegel,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta: transforming growth factor beta2 research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta: transforming growth factor beta2 research

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Anti-TGF-beta2 antibody therapy inhibits postoperative resynostosis in craniosynostotic rabbits. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Plastic and reconstructive surgery

VOLUME: 119

Page Numbers: 1200-12; discussion 1213-5

Journal Abbreviation: Plast. Reconstr. Surg.

ISSN: 1529-4242

DAY: 1

MONTH: Apr

YEAR: 2007

Anti-TGF-beta2 antibody therapy inhibits postoperative resynostosis in craniosynostotic rabbits. Information

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LANGUAGE: eng

NlmUniqueID: 1306050

Anti-TGF-beta2 antibody therapy inhibits postoperative resynostosis in craniosynostotic rabbits. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta2

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Anti-TGF-beta2 antibody therapy inhibits postoperative resynostosis in craniosynostotic rabbits. Information

Substance Name: Transforming Growth Factor beta2

Registry Number: 0

Grant and Affiliation Information for Anti-TGF-beta2 antibody therapy inhibits postoperative resynostosis in craniosynostotic rabbits.

AFFILIATION: Department of Oral Medicine and Pathology, the Cleft Palate-Craniofacial Center, and the School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA. mpm4@pitt.edu

Country: United States

AGENCY: United States NIDCR

GRANT: DE13078

ACRONYM: DE

MEDLINETA: Plast Reconstr Surg

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