Anti-OX40 stimulation in vivo enhances CD8+ memory T cell survival and significantly increases recall responses.

Anti-OX40 stimulation in vivo enhances CD8+ memory T cell survival and significantly increases recall responses. Research Abstract Details 

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Anti-OX40 stimulation in vivo enhances CD8+ memory T cell survival and significantly increases recall responses. Abstract Text:

Carl E Ruby,William L Redmond,Daniel Haley,Andrew D Weinberg,

There is growing evidence that engagement of OX40 (CD134), a member of the TNF receptor superfamily, can directly stimulate antigen-specific CD8+ T cells. It has been shown that CD8+ T cells express OX40 following activation, but the response of antigen-specific CD8+ T cells to OX40 stimulation has not been fully characterized. We utilized an antigen-specific transgenic CD8+ T cell model (OT-I) to determine if OX40 engagement can boost the generation of antigen-specific CD8+ T cell memory. Our results demonstrate that enhanced OX40 costimulation, via an agonist anti-OX40 antibody, increases CD25 and phospho-Akt expression on the antigen-specific CD8+ T cells and significantly increases the generation of long-lived antigen-specific CD8+ memory T cells. The increased numbers of memory CD8+ T cells generated via anti-OX40 treatment still required the presence of CD4+ T cells for their long-term maintenance in vivo. In addition, anti-OX40 costimulation greatly enhanced antigen-specific CD8+ T cell recall responses. These data show that OX40 engagement in vivo increases the number of antigen-specific CD8+ memory T cells surviving after antigen challenge and has implications for the development of more potent vaccines against pathogens and cancer.

Anti-OX40 stimulation in vivo enhances CD8+ memory T cell survival and significantly increases recall responses. Publishing Authors By Initials

CE Ruby,WL Redmond,D Haley,AD Weinberg,

For similar cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: lymphocyte subsets: t-lymphocyte subsets research abstracts see: cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: lymphocyte subsets: t-lymphocyte subsets research

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Anti-OX40 stimulation in vivo enhances CD8+ memory T cell survival and significantly increases recall responses. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: European journal of immunology

VOLUME: 37

Page Numbers: 157-66

Journal Abbreviation: Eur. J. Immunol.

ISSN: 0014-2980

DAY: 3

MONTH: Jan

YEAR: 2007

Anti-OX40 stimulation in vivo enhances CD8+ memory T cell survival and significantly increases recall responses. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 1273201

Anti-OX40 stimulation in vivo enhances CD8+ memory T cell survival and significantly increases recall responses. Keywords Mesh Terms:

KEYWORDS: T-Lymphocyte Subsets

MESH TERMS: transplantation

Chemical & Substance for Abstract: Anti-OX40 stimulation in vivo enhances CD8+ memory T cell survival and significantly increases recall responses. Information

Substance Name: Tnfrsf4 protein, mouse

Registry Number: 0

Grant and Affiliation Information for Anti-OX40 stimulation in vivo enhances CD8+ memory T cell survival and significantly increases recall responses.

AFFILIATION: Laboratory of Basic Immunology, Earle A. Chiles Research Institute, Robert W. Franz Research Center, Providence Portland Medical Center, Portland, OR 97213, USA.

Country: Germany

AGENCY: United States NCI

GRANT: R01-CA102577-04

ACRONYM: CA

MEDLINETA: Eur J Immunol

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