Anti-NSP4 antibody can block rotavirus-induced diarrhea in mice.

Anti-NSP4 antibody can block rotavirus-induced diarrhea in mice. Research Abstract Details 

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Anti-NSP4 antibody can block rotavirus-induced diarrhea in mice. Abstract Text:

Zongliu Hou,Yongkun Huang,Youming Huan,Wei Pang,Mingyao Meng,Ping Wang,Meifen Yang,Lihong Jiang,Xinan Cao,Kenneth K Wu,Zongliu Hou,Yongkun Huang,Youming Huan,Wei Pang,Mingyao Meng,Ping Wang,Meifen Yang,Lihong Jiang,Xinan Cao,Kenneth K Wu,

BACKGROUND: Rotavirus infection is the most common cause of infectious diarrhea and gastroenteritis among children worldwide. The viral proteins (VP), especially VP4- and VP7-induced neutralizing antibodies, were considered to be critical in protective immunity to rotavirus disease. However, whether the antibody to rotavirus nonstructural protein 4 (NSP4) protects against rotavirus-induced diarrhea directly is not completely clear, especially for the protective time course. MATERIALS AND METHODS: To obtain direct evidence, 12-day-old ICR mice were treated with NSP4 and entire rotavirus to induce diarrhea. RESULTS: Both NSP4 and rotavirus-treated mice developed diarrhea, which was accompanied by histological changes in the small intestine compared to age-matched control mice. Anti-NSP4 antibody demonstrated protection against both entire rotavirus-induced diarrhea and NSP4-induced diarrhea. The histological changes in the small intestinal were reversible. These data show that early intervention with anti-NSP4 antibody can prevent rotavirus-induced diarrhea in mice; late intervention with anti-NSP4 antibody could halt diarrhea progression in mice. CONCLUSIONS: Our findings demonstrate for the first time that administration of anti-NSP4 antibody is effective both prior to and during the time course of rotavirus infection. These observations extend our knowledge of rotavirus infection and its therapeutic options.

Anti-NSP4 antibody can block rotavirus-induced diarrhea in mice. Publishing Authors By Initials

Z Hou,Y Huang,Y Huan,W Pang,M Meng,P Wang,M Yang,L Jiang,X Cao,KK Wu,Z Hou,Y Huang,Y Huan,W Pang,M Meng,P Wang,M Yang,L Jiang,X Cao,KK Wu,

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Anti-NSP4 antibody can block rotavirus-induced diarrhea in mice. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of pediatric gastroenterology and nutritio

VOLUME: 46

Page Numbers: 376-85

Journal Abbreviation: J. Pediatr. Gastroenterol. Nut

ISSN: 1536-4801

DAY: 27

MONTH: Apr

YEAR: 2008

Anti-NSP4 antibody can block rotavirus-induced diarrhea in mice. Information

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LANGUAGE: eng

NlmUniqueID: 8211545

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Grant and Affiliation Information for Anti-NSP4 antibody can block rotavirus-induced diarrhea in mice.

AFFILIATION: Research Laboratory Center, Yan'an Hospital of Kunming City, Kunming, Yunnan, People's Republic of China. hzl579@163.com

Country: United States

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MEDLINETA: J Pediatr Gastroenterol Nutr

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