Anti-leishmania activity of semi-purified fraction of Jacaranda puberula leaves.

Anti-leishmania activity of semi-purified fraction of Jacaranda puberula leaves. Research Abstract Details 

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Anti-leishmania activity of semi-purified fraction of Jacaranda puberula leaves. Abstract Text:

L F D Passero,A A Castro,T Y Tomokane,M J Kato,T F Paulinetti,C E P Corbett,M D Laurenti,

The crude methanolic extract from leaves of Jacaranda puberula showed activity against Leishmania (Leishmania) amazonensis. The extract presented active against promastigote forms with an inhibitory concentration 50% (IC(50)) value of 88.0 mug/ml, but only moderated activity against amastigote forms; however in higher concentrations the extract showed cytotoxic effects. The bio-guided chromatographic fractionation the crude methanolic extract against amastigotes yielded a fraction with an IC(50) value of 14.0 mug/ml (without cytotoxic activity) in relation to the crude extract (IC(50) value, 359.0 microg/ml). These data indicate that J. puberula leaves contain active compounds, which should be further investigated for the development of new potential drugs against cutaneous leishmaniasis.

Anti-leishmania activity of semi-purified fraction of Jacaranda puberula leaves. Publishing Authors By Initials

LF Passero,AA Castro,TY Tomokane,MJ Kato,TF Paulinetti,CE Corbett,MD Laurenti,

For similar plants: plant components: plant components, aerial: plant leaves research abstracts see: plants: plant components: plant components, aerial: plant leaves research

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Anti-leishmania activity of semi-purified fraction of Jacaranda puberula leaves. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Parasitology research

VOLUME: 101

Page Numbers: 677-80

Journal Abbreviation: Parasitol. Res.

ISSN: 0932-0113

DAY: 28

MONTH: 03

YEAR: 2007

Anti-leishmania activity of semi-purified fraction of Jacaranda puberula leaves. Information

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LANGUAGE: eng

NlmUniqueID: 8703571

Anti-leishmania activity of semi-purified fraction of Jacaranda puberula leaves. Keywords Mesh Terms:

KEYWORDS: Plant Leaves

MESH TERMS: chemistry

Chemical & Substance for Abstract: Anti-leishmania activity of semi-purified fraction of Jacaranda puberula leaves. Information

Substance Name: Plant Extracts

Registry Number: 0

Grant and Affiliation Information for Anti-leishmania activity of semi-purified fraction of Jacaranda puberula leaves.

AFFILIATION: Departamento de Patologia, Faculdade de Medicina, Universidade de São Paulo, Av. Dr. Arnaldo 455, Cerqueira César, São Paulo 0146-903, SP, Brazil. felipepassero@yahoo.com.br

Country: Germany

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MEDLINETA: Parasitol Res

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