Anti-inflammatory drug delivery from hyaluronic acid hydrogels.

Anti-inflammatory drug delivery from hyaluronic acid hydrogels. Research Abstract Details 

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Anti-inflammatory drug delivery from hyaluronic acid hydrogels. Abstract Text:

Sei K Hahn,Sandra Jelacic,Ronald V Maier,Patrick S Stayton,Allan S Hoffman,Sei K Hahn,Sandra Jelacic,Ronald V Maier,Patrick S Stayton,Allan S Hoffman,

Two different types of hyaluronic acid (HA) hydrogels were synthesized by crosslinking HA with divinyl sulfone (DVS) and poly(ethylene glycol)-divinyl sulfone (VS-PEG-VS). Vitamin E succinate (VES), an anti-inflammatory drug, and bovine serum albumin (BSA), a model of anti-inflammatory protein drugs, were loaded into the gels and their release kinetics were measured in vitro. VES and BSA released with a burst from both HA hydrogels during the first few hours, and release continued gradually for several days. The rate of release from HA-VS-PEG-VS-HA hydrogels was faster than that from HA-DVS-HA hydrogels, presumably due to the lower crosslink density in the former. The anti-inflammatory action of released VES was tested by incubating peripheral blood mononuclear cells (PBMC) on HA hydrogels with and without VES in the gel. The number of cells adhering on HA hydrogels was very low compared to that on tissue culture polystyrene (TCPS), which might be one of the important advantages of using HA hydrogels for implant coatings or tissue engineering applications. ELISA test results showed that the tumor necrosis factor-alpha (TNF-alpha) concentration was very low in the supernatant of the wells containing the HA hydrogel with VES in contact with the activated macrophages compared to that without VES. This is probably the effect of the released VES reducing the production of anti-inflammatory cytokine, TNF-alpha. HA hydrogels containing anti-inflammatory drugs may have potential for use in tissue engineering and also as biocompatible coatings of implants.

Anti-inflammatory drug delivery from hyaluronic acid hydrogels. Publishing Authors By Initials

SK Hahn,S Jelacic,RV Maier,PS Stayton,AS Hoffman,SK Hahn,S Jelacic,RV Maier,PS Stayton,AS Hoffman,

For similar heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e research abstracts see: heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e research

PUBMED ID PMID:

MEDLINE DATE:

Anti-inflammatory drug delivery from hyaluronic acid hydrogels. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of biomaterials science. Polymer edition

VOLUME: 15

Page Numbers: 1111-9

Journal Abbreviation:

ISSN: 0920-5063

DAY: 19

MONTH: 11

YEAR: 2004

Anti-inflammatory drug delivery from hyaluronic acid hydrogels. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9007393

Anti-inflammatory drug delivery from hyaluronic acid hydrogels. Keywords Mesh Terms:

KEYWORDS: Vitamin E

MESH TERMS: analogs & derivatives

Chemical & Substance for Abstract: Anti-inflammatory drug delivery from hyaluronic acid hydrogels. Information

Substance Name: Hyaluronic Acid

Registry Number: 9004-61-9

Grant and Affiliation Information for Anti-inflammatory drug delivery from hyaluronic acid hydrogels.

AFFILIATION: Department of Bioengineering, University of Washington, Seattle, WA 98195, USA. sekanhn@chugai-pharm.co.jp

Country: Netherlands

AGENCY: United States NHLBI

GRANT: R24 HL 64387

ACRONYM: HL

MEDLINETA: J Biomater Sci Polym Ed

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