Anti-ganglioside antibodies alter presynaptic release and calcium influx.

Anti-ganglioside antibodies alter presynaptic release and calcium influx. Research Abstract Details 

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Anti-ganglioside antibodies alter presynaptic release and calcium influx. Abstract Text:

Brigitte Buchwald,Gang Zhang,Angela K Vogt-Eisele,Weiyi Zhang,Raheleh Ahangari,John W Griffin,Hanns Hatt,Klaus V Toyka,Kazim A Sheikh,Brigitte Buchwald,Gang Zhang,Angela K Vogt-Eisele,Weiyi Zhang,Raheleh Ahangari,John W Griffin,Hanns Hatt,Klaus V Toyka,Kazim A Sheikh,

Acute motor axonal neuropathy (AMAN) variant of Guillain-Barré syndrome is often associated with IgG anti-GM1 and -GD1a antibodies. The pathophysiological basis of antibody-mediated selective motor nerve dysfunction remains unclear. We investigated the effects of IgG anti-GM1 and -GD1a monoclonal antibodies (mAbs) on neuromuscular transmission and calcium influx in hemidiaphragm preparations and in cultured neurons, respectively, to elucidate mechanisms of Ab-mediated muscle weakness. Anti-GM1 and -GD1a mAbs depressed evoked quantal release to a significant yet different extent, without affecting postsynaptic currents. At equivalent concentrations, anti-GD1b, -GT1b, or sham mAbs did not affect neuromuscular transmission. At fourfold higher concentration, an anti-GD1b mAb (specificity described in immune sensory neuropathies) induced completely reversible blockade. In neuronal cultures, anti-GM1 and -GD1a mAbs significantly reduced depolarization-induced calcium influx. In conclusion, different anti-ganglioside mAbs induce distinct effects on presynaptic transmitter release by reducing calcium influx, suggesting that this is one mechanism of antibody-mediated muscle weakness in AMAN.

Anti-ganglioside antibodies alter presynaptic release and calcium influx. Publishing Authors By Initials

B Buchwald,G Zhang,AK Vogt-Eisele,W Zhang,R Ahangari,JW Griffin,H Hatt,KV Toyka,KA Sheikh,B Buchwald,G Zhang,AK Vogt-Eisele,W Zhang,R Ahangari,JW Griffin,H Hatt,KV Toyka,KA Sheikh,

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Anti-ganglioside antibodies alter presynaptic release and calcium influx. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Neurobiology of disease

VOLUME: 28

Page Numbers: 113-21

Journal Abbreviation: Neurobiol. Dis.

ISSN: 0969-9961

DAY: 14

MONTH: 07

YEAR: 2007

Anti-ganglioside antibodies alter presynaptic release and calcium influx. Information

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LANGUAGE: eng

NlmUniqueID: 9500169

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Grant and Affiliation Information for Anti-ganglioside antibodies alter presynaptic release and calcium influx.

AFFILIATION: Research Group Neurophysiology, Section Neurology, Max-Planck-Institute of Psychiatry, Munich, Germany.

Country: United States

AGENCY: United States NINDS

GRANT: NS54962

ACRONYM: NS

MEDLINETA: Neurobiol Dis

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