Anti-cardiolipin and increased serum adhesion molecule levels in patients with aggressive periodontitis.

Anti-cardiolipin and increased serum adhesion molecule levels in patients with aggressive periodontitis. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Anti-cardiolipin and increased serum adhesion molecule levels in patients with aggressive periodontitis. Abstract Text:

Harvey A Schenkein,Al M Best,Carol N Brooks,John A Burmeister,James A Arrowood,Michael C Kontos,John G Tew,

BACKGROUND: We observed that a significant proportion of patients with periodontitis have elevated serum levels of beta2-glycoprotein-I-dependent anti-cardiolipin (anti-CL). These prothrombotic autoantibodies, commonly found to be elevated in patients with systemic lupus erythematosus and the antiphospholipid syndrome, are associated with adverse pregnancy outcomes, such as fetal involution, prematurity, and low birth weight, and with cardiovascular sequelae, such as atherosclerosis, stroke, and myocardial infarction. Anti-CL is known to promote vascular inflammation and thrombosis. METHODS: We measured serum levels of markers of vascular inflammation, including soluble intercellular adhesion molecule (sICAM)-1, soluble vascular cell adhesion molecule (sVCAM)-1, and sE-selectin, in 190 subjects with generalized aggressive or chronic periodontitis and in 90 periodontally healthy subjects. RESULTS: sVCAM-1 and sE-selectin levels were significantly higher in patients with elevated anti-CL (>15 U/ml). This relationship also was observed in the never-smoker subset of subjects, even after correction for demographic and periodontal variables. Within the diagnostic categories, sICAM-1, sVCAM-1, and sE-selectin were significantly higher in generalized aggressive periodontitis patients who had elevated anti-CL compared to those with normal anti-CL. Statistical correction for demographic and periodontal variables indicated that elevated anti-CL remained significantly associated with increased sVCAM-1 and sE-selectin in generalized aggressive periodontitis patients. CONCLUSIONS: Systemic markers of vascular inflammation in patients with aggressive periodontitis are associated with elevated levels of anti-CL. We hypothesize that a subset of periodontitis patients with elevated antiphospholipid antibodies could represent a subgroup at increased risk for obstetrical and cardiovascular sequelae.

Anti-cardiolipin and increased serum adhesion molecule levels in patients with aggressive periodontitis. Publishing Authors By Initials

HA Schenkein,AM Best,CN Brooks,JA Burmeister,JA Arrowood,MC Kontos,JG Tew,

For similar cardiovascular diseases: vascular diseases: vasculitis research abstracts see: cardiovascular diseases: vascular diseases: vasculitis research

PUBMED ID PMID:

MEDLINE DATE:

Anti-cardiolipin and increased serum adhesion molecule levels in patients with aggressive periodontitis. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of periodontology

VOLUME: 78

Page Numbers: 459-66

Journal Abbreviation: J. Periodontol.

ISSN: 0022-3492

DAY: 3

MONTH: Mar

YEAR: 2007

Anti-cardiolipin and increased serum adhesion molecule levels in patients with aggressive periodontitis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8000345

Anti-cardiolipin and increased serum adhesion molecule levels in patients with aggressive periodontitis. Keywords Mesh Terms:

KEYWORDS: Vasculitis

MESH TERMS: immunology

Chemical & Substance for Abstract: Anti-cardiolipin and increased serum adhesion molecule levels in patients with aggressive periodontitis. Information

Substance Name: Intercellular Adhesion Molecule-1

Registry Number: 126547-89-5

Grant and Affiliation Information for Anti-cardiolipin and increased serum adhesion molecule levels in patients with aggressive periodontitis.

AFFILIATION: Clinical Research Center for Periodontal Disease, Virginia Commonwealth University School of Dentistry, Richmond, VA 23298, USA. haschenk@vcu.edu

Country: United States

AGENCY: United States NIDCR

GRANT: DE 13102

ACRONYM: DE

MEDLINETA: J Periodontol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Anti-cardiolipin and increased serum adhesion molecule levels in patients with aggressive periodontitis Related Publications

• "Skittish" Abca2 knockout mice display tremor, hyperactivity, and abnormal myelin ultrastructure in the central nervous system.
• A METHOD OF RECORDING SINGLE CELL DISCHARGES IN THE CEREBRAL CORTEX OF MAN.
• A randomized trial of family caregiver support in the home management of dementia.
• ABCA2 as a therapeutic target in cancer and nervous system disorders.
• Anterior urethral value: An uncommon cause of urethral obstruction.
• Anti-cardiolipin and increased serum adhesion molecule levels in patients with aggressive periodontitis.
• Antimicrobial polymers prepared by ROMP with unprecedented selectivity: a molecular construction kit approach.
• Articular changes associated with a flexion deformity in rheumatoid and osteoarthritic knees.
• Community study of hypothyroidism in Down's syndrome.
• Conformationally rigid proteomimetics: a case study in designing antimicrobial aryl oligomers.
• Cytokines and inflammatory factors regulating immunoglobulin production in aggressive periodontitis.
• Desensitization of aircraft.
• Follicular dendritic cell (FDC)-FcgammaRIIB engagement via immune complexes induces the activated FDC phenotype associated with secondary follicle development.
• Immune complex-bearing follicular dendritic cells deliver a late antigenic signal that promotes somatic hypermutation.
• Influence of lipid composition on membrane activity of antimicrobial phenylene ethynylene oligomers.
• Intended place of delivery and perinatal outcome.
• Is the KT1000 knee ligament arthrometer reliable?
• NOV-002, a glutathione disulfide mimetic, as a modulator of cellular redox balance.
• NOV-002, a mimetic of glutathione disulfide.
• Protein cysteine sulfinic acid reductase (sulfiredoxin) as a regulator of cell proliferation and drug response.
• Rapid tissue factor induction by oral streptococci and monocyte-IL-1beta.
• Second order coalescence conditions of molecular wave functions.
• Synthesis of macrocycle isomers via metathesis cyclization and their self-assembly from aqueous solutions.
• Synthesis of urea oligomers and their antibacterial activity.
• Synthetic mimics of antimicrobial peptides.
• TLR4 on follicular dendritic cells: an activation pathway that promotes accessory activity.
• The origin of the scalp recorded P14 following electrical stimulation of the median nerve: intraoperative observations.
• The reliability of prediction of outcome in spina bifida.
• The role of the extrastriate body area in action perception.
• Utility, safety, and accuracy of intraoperative angiography in the surgical treatment of aneurysms and arteriovenous malformations.