Anti-AIDS agents 73: Structure-activity relationship study and asymmetric synthesis of 3-O-monomethylsuccinyl-betulinic acid derivatives.

Anti-AIDS agents 73: Structure-activity relationship study and asymmetric synthesis of 3-O-monomethylsuccinyl-betulinic acid derivatives. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Anti-AIDS agents 73: Structure-activity relationship study and asymmetric synthesis of 3-O-monomethylsuccinyl-betulinic acid derivatives. Abstract Text:

Keduo Qian,Kyoko Nakagawa-Goto,Donglei Yu,Susan L Morris-Natschke,Theodore J Nitz,Nicole Kilgore,Graham P Allaway,Kuo-Hsiung Lee,Keduo Qian,Kyoko Nakagawa-Goto,Donglei Yu,Susan L Morris-Natschke,Theodore J Nitz,Nicole Kilgore,Graham P Allaway,Kuo-Hsiung Lee,

3-O-3'(or 2')-Methylsuccinyl-betulinic acid (MSB) derivatives were separated by using recycle HPLC. The structures of four isomers were assigned by NMR and asymmetric synthesis. 3-O-3'S-Methylsuccinyl-betulinic acid (3'S-MSB, 4) exhibited potent anti-HIV activity with an EC(50) value of 0.0087muM and a TI value of 6.3x10(3), which is comparable to the data for bevirimat (DSB, PA-457), a current clinical trials drug that was also derived from betulinic acid. The anti-HIV potency of 4 was slightly better than that of AZT.

Anti-AIDS agents 73: Structure-activity relationship study and asymmetric synthesis of 3-O-monomethylsuccinyl-betulinic acid derivatives. Publishing Authors By Initials

K Qian,K Nakagawa-Goto,D Yu,SL Morris-Natschke,TJ Nitz,N Kilgore,GP Allaway,KH Lee,K Qian,K Nakagawa-Goto,D Yu,SL Morris-Natschke,TJ Nitz,N Kilgore,GP Allaway,KH Lee,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Anti-AIDS agents 73: Structure-activity relationship study and asymmetric synthesis of 3-O-monomethylsuccinyl-betulinic acid derivatives. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Bioorganic & medicinal chemistry letters

VOLUME: 17

Page Numbers: 6553-7

Journal Abbreviation: Bioorg. Med. Chem. Lett.

ISSN: 0960-894X

DAY: 1

MONTH: Dec

YEAR: 2007

Anti-AIDS agents 73: Structure-activity relationship study and asymmetric synthesis of 3-O-monomethylsuccinyl-betulinic acid derivatives. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9107377

Anti-AIDS agents 73: Structure-activity relationship study and asymmetric synthesis of 3-O-monomethylsuccinyl-betulinic acid derivatives. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Anti-AIDS agents 73: Structure-activity relationship study and asymmetric synthesis of 3-O-monomethylsuccinyl-betulinic acid derivatives. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Anti-AIDS agents 73: Structure-activity relationship study and asymmetric synthesis of 3-O-monomethylsuccinyl-betulinic acid derivatives.

AFFILIATION: Natural Products Research Laboratories, School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Bioorg Med Chem Lett

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Anti-AIDS agents 73: Structure-activity relationship study and asymmetric synthesis of 3-O-monomethylsuccinyl-betulinic acid derivatives Related Publications

• A differential response of two putative mammalian circadian regulators, mper1 and mper2, to light.
• Actual Conditions and Countermeasure of Yun-bian Old Men's Health.
• Aspirin changes the secretion rate and amino acid composition of human small intestinal mucin in subjects with ileal conduits.
• Bone morphogenetic protein-2 facilitates expression of chondrogenic, not osteogenic, phenotype of human intervertebral disc cells.
• Channel architecture in maltoporin: dominance studies with lamB mutations influencing maltodextrin binding provide evidence for independent selectivity filters in each subunit.
• Compensation. Costly to a fault.
• Design and feasibility of quick EXAFS scans for a 'broomstick' double-crystal monochromator at PLS beamline.
• Directed evolution of the lambda receptor of Escherichia coli through affinity chromatographic selection.
• Effects of dietary vitamin E supplementation on lipid oxidation and volatiles content of irradiated, cooked turkey meat patties with different packaging.
• Exclusion of high-molecular-weight maltosaccharides by lipopolysaccharide O-antigen of Escherichia coli and Salmonella typhimurium.
• Family decision making for elderly patients in the intensive care unit.
• Identification of an osteogenic protein-1 responsive element in the aggrecan promoter.
• Impairment of conjunctival glutathione secretion and ion transport by oxidative stress in an adenovirus type 5 ocular infection model of pigmented rabbits.
• Inactivation of the PTEN gene protein product is associated with the invasiveness and metastasis, but not angiogenesis, of breast cancer.
• Isolation, by affinity chromatography, of mutant escherichia coli cells with novel regulation of lamB expression.
• Longitudinal clivus fracture associated with trapped basilar artery: unusual survival with good neurological recovery.
• MPer1 and mper2 are essential for normal resetting of the circadian clock.
• Model construction on quality of family caregiving in the elderly.
• Nonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock.
• Photoionization studies of sulfur radicals and products of their reactions.
• Posterior transarticular screw fixation for chronic atlanto-axial instability.
• Reciprocal regulation of haem biosynthesis and the circadian clock in mammals.
• Restoration of a loose implant supported crown: a case report.
• Significance of chronic epilepsy in glial tumors and correlation with surgical strategies.
• The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo.
• The effects of permeation enhancers on the surface morphology of the rat nasal mucosa: a scanning electron microscopy study.
• The influence of maltoporin affinity on the transport of maltose and maltohexaose into Escherichia coli.
• Tissue-specific expression, heat inducibility, and biological roles of two hsp16 genes in Caenorhabditis elegans.
• Up-regulation of MUC5AC and MUC5B mucin genes in chronic rhinosinusitis.
• [Expression of MUC3, MUC5AC, MUC6 and epidermal growth factor receptor in gallbladder epithelium according to gallstone composition]