Anthropometric risk factors for colorectal polyps in african-american women.

Anthropometric risk factors for colorectal polyps in african-american women. Research Abstract Details 

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Anthropometric risk factors for colorectal polyps in african-american women. Abstract Text:

Lauren A Wise,Lynn Rosenberg,Julie R Palmer,Lucile L Adams-Campbell,

Objective:Colorectal adenomas are thought to be precursor lesions to colorectal cancer, a leading cause of cancer incidence and mortality in African-American women. Studies suggest that obesity is associated with risk of adenomas in white women, but little is known about the relation in African-American women. We prospectively examined the association between selected anthropometric factors and colorectal polyps in African-American women.Methods and Procedures:Data were obtained from the Black Women's Health Study (BWHS), a prospective cohort study of African-American women. From 1997 to 2003, we followed 33,403 women aged >/=30 years with no prior diagnosis of cancer or polyps. Cox regression was used to estimate incidence rate ratios (IRRs) and 95% confidence intervals (CIs) for risk of polyps, with adjustment for potential confounders.Results:After 211,797 person-years of follow-up, 1,189 cases of colorectal polyps were reported. The IRR comparing women with a current BMI >/=35 to <25 kg/m(2) was 1.35 (95% CI = 1.12-1.62), after adjustment for covariates including waist-to-hip ratio (WHR). Women who gained >/=30 kg since age 18 were 1.76 times as likely as those who gained <5 kg to report polyps (95% CI = 1.33-2.33). The IRR comparing the highest (>/=0.87) to lowest (<0.71) quintiles of WHR was 1.26 (95% CI = 1.04-1.54), after adjustment for covariates including BMI. BMI at age 18, adult height, and waist circumference (BMI-adjusted) were not materially associated with risk. Results were similar among women with a recent endoscopy.Discussion:Weight gain and obesity in adulthood may increase the risk of colorectal polyps in African-American women.Obesity (2008) 16 4, 859-868. doi:10.1038/oby.2007.139.

Anthropometric risk factors for colorectal polyps in african-american women. Publishing Authors By Initials

LA Wise,L Rosenberg,JR Palmer,LL Adams-Campbell,

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Anthropometric risk factors for colorectal polyps in african-american women. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Obesity (Silver Spring, Md.)

VOLUME: 16

Page Numbers: 859-68

Journal Abbreviation: Obesity (Silver Spring)

ISSN: 1930-7381

DAY: 24

MONTH: 01

YEAR: 2008

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LANGUAGE: eng

NlmUniqueID: 101264860

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AFFILIATION: 1Slone Epidemiology Center at Boston University, Boston, Massachusetts, USA.

Country: United States

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MEDLINETA: Obesity (Silver Spring)

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