Anthraquinones from the seeds of Cassia tora with inhibitory activity on protein glycation and aldose reductase.

Anthraquinones from the seeds of Cassia tora with inhibitory activity on protein glycation and aldose reductase. Research Abstract Details 

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Anthraquinones from the seeds of Cassia tora with inhibitory activity on protein glycation and aldose reductase. Abstract Text:

Dae Sik Jang,Ga Young Lee,Young Sook Kim,Yun Mi Lee,Chan-Sik Kim,Jeong Lim Yoo,Jin Sook Kim,Dae Sik Jang,Ga Young Lee,Young Sook Kim,Yun Mi Lee,Chan-Sik Kim,Jeong Lim Yoo,Jin Sook Kim,

Nine anthraquinones, aurantio-obtusin (1), chryso-obtusin (2), obtusin (3), chryso-obtusin-2-O-beta-D-glucoside (4), physcion (5), emodin (6), chrysophanol (7), obtusifolin (8), and obtusifolin-2-O-beta-D-glucoside (9), isolated from an EtOAc-soluble extract of the seeds of Cassia tora, were subjected to in vitro bioassays to evaluate their inhibitory activity against advanced glycation end products (AGEs) formation and rat lens aldose reductase (RLAR). Among the isolates, compounds 6 and 8 exhibited a significant inhibitory activity on AGEs formation with observed IC(50) values of 118 and 28.9 microM, respectively, in an AGEs-bovine serum albumin (BSA) assay by specific fluorescence. Furthermore, compounds 6 and 8 inhibited AGEs-BSA formation more effectively than aminoguanidine, an AGEs inhibitor, by indirect AGEs-ELISA. N(epsilon)-Carboxymethyllysine (CML)-BSA formation was also inhibited by compounds 6 and 8. Whereas compounds 1, 4, and 6 showed a significant inhibitory activity on RLAR with IC(50) values of 13.6, 8.8, and 15.9 microM, respectively.

Anthraquinones from the seeds of Cassia tora with inhibitory activity on protein glycation and aldose reductase. Publishing Authors By Initials

DS Jang,GY Lee,YS Kim,YM Lee,CS Kim,JL Yoo,JS Kim,DS Jang,GY Lee,YS Kim,YM Lee,CS Kim,JL Yoo,JS Kim,

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Anthraquinones from the seeds of Cassia tora with inhibitory activity on protein glycation and aldose reductase. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biological & pharmaceutical bulletin

VOLUME: 30

Page Numbers: 2207-10

Journal Abbreviation: Biol. Pharm. Bull.

ISSN: 0918-6158

DAY: 5

MONTH: Nov

YEAR: 2007

Anthraquinones from the seeds of Cassia tora with inhibitory activity on protein glycation and aldose reductase. Information

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LANGUAGE: eng

NlmUniqueID: 9311984

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Grant and Affiliation Information for Anthraquinones from the seeds of Cassia tora with inhibitory activity on protein glycation and aldose reductase.

AFFILIATION: Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine, 461-24 Jeonmin-dong, Yuseong-gu, Daejeon, Korea.

Country: Japan

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MEDLINETA: Biol Pharm Bull

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