Anthranilamide inhibitors of factor Xa.

Anthranilamide inhibitors of factor Xa. Research Abstract Details 

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Anthranilamide inhibitors of factor Xa. Abstract Text:

David Mendel,Angela L Marquart,Sajan Joseph,Philip Waid,Ying K Yee,Anne Louise Tebbe,Andrew M Ratz,David K Herron,Theodore Goodson,John J Masters,Jeffry B Franciskovich,Jennifer M Tinsley,Michael R Wiley,Leonard C Weir,Jeffrey A Kyle,Valentine J Klimkowski,Gerald F Smith,Richard D Towner,Larry L Froelich,John Buben,Trelia J Craft,

SAR about the B-ring of a series of N(2)-aroyl anthranilamide factor Xa (fXa) inhibitors is described. B-ring o-aminoalkylether and B-ring p-amine probes of the S1' and S4 sites, respectively, afforded picomolar fXa inhibitors that performed well in in vitro anticoagulation assays.

Anthranilamide inhibitors of factor Xa. Publishing Authors By Initials

D Mendel,AL Marquart,S Joseph,P Waid,YK Yee,AL Tebbe,AM Ratz,DK Herron,T Goodson,JJ Masters,JB Franciskovich,JM Tinsley,MR Wiley,LC Weir,JA Kyle,VJ Klimkowski,GF Smith,RD Towner,LL Froelich,J Buben,TJ Craft,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: structure-activity relationship research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: structure-activity relationship research

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Anthranilamide inhibitors of factor Xa. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Bioorganic & medicinal chemistry letters

VOLUME: 17

Page Numbers: 4832-6

Journal Abbreviation: Bioorg. Med. Chem. Lett.

ISSN: 0960-894X

DAY: 20

MONTH: 06

YEAR: 2007

Anthranilamide inhibitors of factor Xa. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9107377

Anthranilamide inhibitors of factor Xa. Keywords Mesh Terms:

KEYWORDS: Structure-Activity Relationship

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Anthranilamide inhibitors of factor Xa. Information

Substance Name: Factor Xa

Registry Number: EC 3.4.21.6

Grant and Affiliation Information for Anthranilamide inhibitors of factor Xa.

AFFILIATION: Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA. mendel_david@lilly.com

Country: England

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MEDLINETA: Bioorg Med Chem Lett

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