Antenatal betamethasone administration has a dual effect on adult sheep vascular reactivity.

Antenatal betamethasone administration has a dual effect on adult sheep vascular reactivity. Research Abstract Details 

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Antenatal betamethasone administration has a dual effect on adult sheep vascular reactivity. Abstract Text:

Victor M Pulgar,Jorge P Figueroa,

The effect of antenatal steroids on blood pressure in humans remains an unresolved question. Here we report the effects of prenatal exposure to clinically relevant doses of betamethasone on endothelial and/or vascular smooth muscle function. Pregnant sheep were randomly treated with betamethasone (0.17 mg/kg) or vehicle at 80 and 81 d of gestation. We studied arterial segments (4th-5th generation) of the right brachial artery obtained at 1-2 y of age under general anesthesia. We demonstrate that in brachial arteries of steroid exposed offspring: KCl induced contraction is increased after endothelium removal or incubation with inhibitors of nitric oxide synthase or cyclooxygenase; acetylcholine-induced relaxation is increased; sensitivity to endothelin-1 (ET-1) is increased and this effect is decreased by the ETB antagonist BQ-788. These data suggest that, in sheep treated with clinically relevant doses of betamethasone at a gestational stage when human fetuses are routinely exposed to glucocorticoids, there is a dual effect of betamethasone on the adult sheep brachial artery, i.e. endothelial dysfunction with an impairment of endothelin-1 ETB receptor-induced release of nitric oxide and an increased contribution of the ETB receptor in smooth muscle to the contractile effects of ET-1.

Antenatal betamethasone administration has a dual effect on adult sheep vascular reactivity. Publishing Authors By Initials

VM Pulgar,JP Figueroa,

For similar chemical actions and uses: pharmacologic actions: therapeutic uses: cardiovascular agents: vasodilator agents research abstracts see: chemical actions and uses: pharmacologic actions: therapeutic uses: cardiovascular agents: vasodilator agents research

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Antenatal betamethasone administration has a dual effect on adult sheep vascular reactivity. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Pediatric research

VOLUME: 60

Page Numbers: 705-10

Journal Abbreviation: Pediatr. Res.

ISSN: 0031-3998

DAY: 25

MONTH: 10

YEAR: 2006

Antenatal betamethasone administration has a dual effect on adult sheep vascular reactivity. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100714

Antenatal betamethasone administration has a dual effect on adult sheep vascular reactivity. Keywords Mesh Terms:

KEYWORDS: Vasodilator Agents

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Antenatal betamethasone administration has a dual effect on adult sheep vascular reactivity. Information

Substance Name: Potassium Chloride

Registry Number: 7447-40-7

Grant and Affiliation Information for Antenatal betamethasone administration has a dual effect on adult sheep vascular reactivity.

AFFILIATION: Center for Research in Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL68728

ACRONYM: HL

MEDLINETA: Pediatr Res

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